Abstract: Objective To clinically evaluate the effects of guided bone regeneration (GBR) in peri-implant bone defects with acellular dermal matrices(ADM). Methods A total number of 22 patients undergoing implant treatment in our department of stomatology from July 2008 to July 2011 were selected. Among them 12 were men and 10 were women, aging from 21 to 62 (with the average age of 43.8). There were altogether 28 implants. All the 28 implants were placed in the thin alveolar ridges of patients with buccal or labial bone defects. The bone defects were covered with admixture of HA-coral particles and autogenous bone, and then the surfaces of the particles were covered with acellular dermal matrix membranes. Clinical examination was conducted to follow up the healing of the acellular dermal matrix. Results The acellular dermal matrix membranes of 1 case were exposed and removed 1 month later due to a localized infection. One implant was removed three years later because of loosening.All of the other peri-implant bone defects of the rest patients were completely covered with new formed bones in the second stage of operation 6 months later. The length of the exposed part of the implants was zero. Conclusion ADM membrane has excellent biocompatibility and biodegradablility and can be used in guided bone regeneration to promote the bone repair progress clinically.