Abstract: Objective To sum up the clinical application of diagnostic waxup in the esthetic anterior teeth restorations with CAD/CAM all ceramic restorations. Methods 110 patients with 137 allceramic crowns were clinically enrolled in this study.First,dianostic waxup used in the esthetic anterior teeth restorations to help dentists communicate with patients; secondly,the shapes of wax frameworks and abutment teeth were captured and digitized by Sirona inEos system,and each individually shaped framework to grant a precise zirconia coping was created based on the reduced program of inLab V3.80 software.All restorations were veneered with VITA VM9. Results During the 18 months′ followup visit,none of the allceramic zirconia restorations had to be replaced due to framework fracture or unrestorable delamination of the ceramic veneer,the marginal fitness of restoration was quite well,and the shape and colour of all restorations satisfied the patients. Conclusions Based on the results of this study,it can be concluded that,diagnostic waxup is useful in helping dentists communicate with patients; allceramic crowns made by CAD/CAM reduced program can make proper room for veneering ceramic,which is helpful to improve the quality of allceramic zirconia restorations.