Abstract: Abstract： Objective To evaluate the influence of three kinds of hot acid solution on short-term shear bond strength of zirconia to resin. Methods 40 zirconia ceramic slices were obtained. After sandblasting, they were divided into 5 groups based on the surface treatment to be applied: group A: H2SO4 / (NH4)2SO4 hot mixed solution etching + application of 10-MDP contained primer Clearfil; group B: HF / HNO3 hot mixed solution etching + application of Clearfil; group C: H2SO4 / HF / HNO3 hot mixed solution etching + application of Clearfil; group D: application of Clearfil; E: no further treatment. Shear bond strength of the specimens was tested and statistically analyzed. The morphology of zirconia surfaces treated by sandblasting with or without hot mixed solution etching was observed with a scanning electron microscope (SEM). Results The shear bond strength of group E was the lowest （3.03±0.94） MPa. The shear bond strength of group B was the second lowest（7.53±1.37） Mpa. The shear bond strength of group A, B, and C was higher than that of the other two groups, which was respectively （9.16±1.12） MPa，（8.89±1.06） MPa，（8.95±1.36） MPa (P<0.05), while no statistical difference was found between the three acid etched groups. SEM images showed obvious morphological difference between groups treated by sandblasting with hot mixed solution etching and groups treated only by sandblasting. Morphology of surfaces treated with three kinds of mixed etching solution was also obviously different. Conclusion Hot acid solution etching combined with application of 10-MDP contained primer provided better bonding for zirconia.