Abstract: Objective　To observe the age-related changes of bone thickness in implant area and insertion direction of zygomatic implants. Methods　A total of 150 eligible cases chosen randomly were scanned with CBCT system. All the cases were divided into three groups, defined as occlusion established group, adult group and elderly group by age. With 3-dimensional (3D) images processed by SimPlant, simulate classic zygomatic implant installing operatetion, and bone region with implant in was equally divided into three parts. Zygomatic and maxillary thickness was obtained on the four equant points. Angular between installing direction and plane Md, CR and FH were measured. Results　The mean thickness of maxilla and zygoma in implatation region on each equant point in the three age groups was (6.62±0.14)mm, (8.35±0.27)mm, (9.06±0.23)mm respectively, and there were significant differences among the three groups （P<0.05）, while that in dentate and edentulous subgroup was (8.82±1.97)mm、(9.37±1.78)mm respectively with no statistically significant difference. There was significant difference among different age groups in installing direction（P<0.05）.Gender was not a significant factor（P>0.05）. Conclusion　Bone thickness in implatation region increases with age in classic zygomatic implant method, and zygoma could give a sufficient support for implantation.