Abstract: To evaluate asymmetry of bilateral condyle in different-age-group patients with mandible deviation based on 3D model reconstructed with 3D CT images.Methods A total of thirty-six patients diagnosed with mandibular deviation were included, and they were divided into three groups by age.The first group included twelve children aged 8 to 11 years old in their mixed dentition period; the second group included twelve youngs aged 11 to 16 years old with early permanent dentition; the third group included twelve adults aged 18 to 30 years old. Every person was scanned with 3-dimensional cone-beam computed tomography (CBCT). Craniofacial DICOM data were acquired. Three-dimensional reconstruction and parameter measurement were done to bone tissue with Simplant software. The results were analyzed statistically. Results There were differences in condylar morphology among different-age-group patients. There was no significant difference in condylar morphology on two sides in mixed dentition period. In the young permanent dentition stage, there was difference in condylar height, condylar transverse dimension, mandibular ramus height, and condylar gradient of back bevel between the contralateral side and ipsilateral side. Bilateral condylar morphology changed asymmetrically. There was significant asymmetrical difference of bilateral condylar morphology in adult patients with mandibular deviation. Compared with the ipsilateral side, condylar height, mandibular ramus height, and condylar transverse dimension were larger on the contralateral side while both the inclination and length of the posterior cant of condyle on the contralateral side were smaller. Conclusions Mandibular deviation may lead to asymmetric remodeling in the condyle. From patients in mixed dentition period to adult patients with mandibular deviation, there was a trend from the mandibular shift to the skeleton abnormal development, so patients with mandibular deviation should receive early treatment.