Abstract: Objective To investigate the expression of IFNγ and IL10 before and after periimplantitis animal models were built.Methods Select 5 beagle dogs,extract premolars in each dog.3 months after extraction,gingiva perforating pure titanium implants were implanted under general anesthesia.3 months after implantation,ligature wires were used to bind the necks of implants for 3 months,and bone defect more than 40% reached the evaluation standard.Before and after periimplantitis models were built,get the gingival crevicular fluid.Contents of IFNγ、IL10 were evaluated by enzymelinked immunosorbent assay before and after periimplantitis models were built.SPSS was used for statistical analysis.Results The mean value of IFNγ in PICF was 6.64 ng/mL,while that in controll group was 2.22 ng/mL（P=0.01）.The mean value of IL10 in PICF was 5.78 ng/mL,while that in the controll group was 4.78 ng/mL（P=0.54）.Conclusions Level of IFNγ increases significantly in PICF,while IL10 increases with no statistical significence in periimplantitis.