Abstract: Objective To observe and evaluate clinical efficacy of bone morphogenetic proteininduced active material (osteoinduction active material,OAM) combined with bone autotransplantation to periodontal tissue regeneration and to investigate the impact of different proportions of OMA mixed with autologous bone on periodontal guided tissue regeneration.Methods Thirtynine teeth with periodontal osseous defects were selected and divided into three groups.Thirteen teeth were cured by guided tissue regeneration(GTR) using OAM mixed with autologous bone in 1∶1(group A),thirteen teeth by GTR using OAM mixed with autologous bone in 2∶1(group B) and thirteen teeth by GTR using OAM merely(group C).Clinical indicators like periodontal probing depth(PPD) clinical attachment loss(CAL) and sulcus bleeding index(SBI) were recoreded before operation,and at 12th,24th week after operations.Results The clinical parameters in three groups showed statistically significant changes compared with baseline for all of the evaluated parameters.PPD and CAL significantly reduced at 12th week after operation(P＜0.05) without significant difference at 24th week(P＞0.05) among three groups.No significant differences of PPD and CAL were found between group A and B.SBI reduce showed no significant difference (P＞0.05) among three groups.Periapical films or CBCT before and after operation demonstrated new bone formation in bone defect areas in three groups.Bone density of group A and group B at 12th week increased more significantly compared with group C.Conclusions OAM combined with bone autotransplantation is an ideal method for periodontal tissue regeneration.In this way,periodontal tissue repair occurs earlier compared with OAM merely.No significant correlation is found between the function of periodontal guided tissue regeneration using OAM mixed with autologous bone and proportions of the mixture.