Abstract: [Abstract] Objective: To evaluate the hemostitic effect and biocompatibity of oral soluble hemostatic guaze as well as its effect on the proliferation of human gingival fibroblasts. Method: Cell culture extracts of soluble hydroxyethyl haemostatic gauze and other hemostatic materials were prepared. Methyl thiazolyl tetrazolium(MTT) assay was used to determine the effect of the materials on the growth of human gingival fibroblast cells. The solubility of the soluble hemostatic gauze in aritificial saliva was observed and the blood clotting index (BCI) in vitro of soluble hemostatic guaze and other hemostatic materials were compared. Result: The solution rate of soluble hemostatic gauze in aritificial saliva was higher. The BCI of soluble hemostatic gauze was significantly lower than that of medical gauze and gelatin sponge and the difference was statistically significant, yet there was no significant difference in cell proliferation rate observed between soluble hemostatic gauze and gelatin sponge. Cytotoxical grade was 0 to 1.Coclusion: The oral soluble hemostatic gauze has showed good solubility and hemostatic effect, and it had no significant cyctoxicity to HGFC.