Abstract: Objective To observe the efficacy and safety of total glucosides of paeony combined with intralesional triamcinolone acetonide injection for oral lichen planus. Methods 58 patients with clinically confirmed erosive and ulcerative OLP were randomly divided into two groups, treated with TGP+TA and TA separately, meanwhile the VAS and REU scoring system was utilized to compare the signs and symptoms. Results There were no statistical significance of effective rate between the treatment group and control group（χ2=0.112，P>0.01）at the first month, there were statistical significance of effective rate between the treatment group and control group（χ2=15.241，P<0.01）at the third month, and so did at the sixth month (χ2=34.621，P<0.01). Conclusion Total glucosides of paeony combined with intralesional triamcinolone acetonide injection can significantly enhance the effect safely in the treatment of OLP.