SPECT/CT同机融合显像在口腔鳞癌前哨淋巴结定位中的应用

Abstract

Abstract: Objective　To explore an accurate and available method in sentinel lymph node localization in cN0 oral squamous cell carcinoma. Methods　Preoperative sentinel lymph node localization by SPECT/CT Co-registration Fusion Scintigraphy and intraoperative sentinel lymph node biopsy were performed to evaluate the cervical lymph node status in 30 cases of cN0 oral squamous cell carcinoma and the pathological results of SLN and neck dissection were compared after the operation. Results　Among all the 30 cases, the accuracy rating of sentinel lymph node localization by SPECT/CT Co-registration Fusion Scintigraphy was 100%. Sentinel lymph nodes were found with metastasis in 8 cases. No non-sentinel lymph node was found with metastasis while sentinel lymph nodes were pathologically negative. The sensitivity, specificity and accuracy of evaluation of neck lymph node metastasis were 100%. Conclusion　Preoperative SPECT/CT Co-registration Fusion Scintigraphy can be used to locate sentinel lymph node and accurately evaluate the statue of cervical lymph node metastasis in cN0 oral squamous cell carcinoma.

Key words: Oral cancer, squamous cell carcinoma, Sentinel lymph node, metastasis

CLC Number:

R739.86

References

[1]Borgstein PJ,Meijer S,Pijpers RJ,et al.Functional Lymphatic anatomy for sentinel node biopsy in breast cancer: echoes from the past and the periareolar blue method[J].Ann Surg,2000,232(1):81-88
[2]李金忠，郑家伟.NCNN头颈癌诊治指南（2007版）(2)[J].　中国口腔颌面外科杂志,2008,6(2):154-160
[3]Pitman KT,Johnson JT,Myers EN.Effectiveness of selective neck dissection for management of the clinically negative neck[J].Arch Otolaryngol,1997,123(9):917-922
[4] Russolo M,Glacomarra V,Papanikolla L,et al.Prognostic indicastors of lccult metastases in oral cancer [J].Laryngo scope,2002,112(7 pt 1):1320-1323
[5]Alex JC,Sasaki CT,Krag DN,et al.Sentinel lymph node radiolocalization in head and neck squamous carcinoma[J].Larygoscope,2000,110(2):198-203
[6]王晓雷，屠规益，唐平章.舌鳞癌无临床颈部淋巴结转移的处理[J].中华口腔医学杂志,2000,35(1):12-14
[7]Shoaib T，Soutar D，Macdonald D，et al.The accuracy of head and neck carcinoma sentinel lymph node biopsy in the clinically N0 neck[J].Cancer,2001,91(11):2077-2083
[8]Hirche C,Murawa D,Mohr Z,et al.ICG fluorescence-guided sentinel node biopsy for axillary nodal staging in breast cancer[J].Breast Cancer. Res Treat,2010,121(2):373-378
[9]张光远，李文涛.乳腺癌前哨淋巴结定位方法研究进展[J].中华放射学杂志,2011,45(7):700-702
[10]O`Connor R,Pezier T,Svhilling C，et al.. The relative cost of sentinel lymph node biopsy in early cancer[J]. J Craniomaxillofac Surg,2013,41(8):-
[11]Civantos FJ,Zitsch RP,Schuller DE,et al.Sentinel lymph node biopsy accurately stages the regional lymph nodes for T1-T2 oral squamous cell carcinomas: results of a prospective multi-institutional trial[J].J Clin Oncol,2010,28(8):1395-400
[12]Govers TM,Hannink G,Merkx MA,et al.Sentinel node biopsy for squamous cell carvinoma of the oral cavity and oropharynx: a diagnostic meta-analysis[J].Oral Oncol,2013,49(8):726-32
[13]姚红磊，纳应坤，刘华.前哨淋巴结活检判断口腔癌颈部淋巴结转移的系统评价[J].实用口腔医学杂志,2012,28(2):66-68
[14]Pitman KT,Johnson JT,Edington H,et al.Lymphatic mapping with isosulfan blue dye in squamous cell carcinoma of the head and neck[J].Arch Otolaryngol Head and Neck Surgery,1998,124:790-793
[15]Koch WM,Choti MA,Civeleck AC,et al.Gamma probe-directed biopsy of the sentinel node in oral squamous cell carcinoma[J].Arch Otolaryngol Head Neck Surg,1998,124:455-459
[16]彭汉伟，曾宗渊，陈福进，等.cN0舌癌前哨淋巴结定位方法研究癌症[J].,2003,22(3):286-290
[17]张胜，刘生，藕小平，等.口腔鳞癌哨位淋巴结融合显像定位的初步研究[J].中国口腔颌面外科杂志,2009,7(1):23-27

The application of SPECT/CT Co-registration Fusion Scintigraphy in Sentinel Lymph Node Localization in cN0 Oral Squamous Cell Carcinoma

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments

[1]	Yingjiao-Xu YingjiaoXu Shan MedicalWang. Research progress on the role of salivary exosomes in oral squamous cell carcinoma [J]. , 2022, 42(7): 664-667.
[2]	. Research progress on the interaction between reactive oxygen species and Hippo pathway in mediating cellular behavior [J]. , 2022, 42(11): 1031-1035.
[3]	. Research progress of curcumin alone and in combination with other drugs against oral squamous cell carcinoma [J]. , 2022, 42(10): 946-950.
[4]	. Construction of clinical prognostic model of oral squamous cell carcinoma based on immune-related genes [J]. , 2022, 42(10): 869-877.
[5]	. Mechanism research of YAP1-FOS promoting cell proliferation, migration and EMT in oral squamous cell carcinoma [J]. , 2019, 39(7): 581-586.
[6]	. Advances in the study of factors related to the occurrence and development of oral squamous cell carcinoma mediated by PI3K/AKT pathway [J]. , 2019, 39(6): 552-556.
[7]	. Influences of long non-coding RNA MEG3 on the proliferation and invasion of HNSCC [J]. , 2019, 39(5): 400-403.
[8]	. Inhibitory effect of danshensu on oral squamous cell carcinoma CAL-27 cells in vitro [J]. , 2019, 39(2): 113-116.
[9]	. Recombinant human lactoferrin inhibits proliferation and induces apoptosis in oral cancer KB cells [J]. , 2018, 38(9): 785-790.
[10]	. A clinicopathological study of the prognosis and metastasis of MMP-14 in oral cancer patients [J]. , 2018, 38(8): 685-689.
[11]	. DNA quantitative analysis of oral squamous cell carcinoma and its clinical significance [J]. , 2018, 38(7): 616-619.
[12]	. Influence of nobelitin on the proliferation，migration and invasion of oral squamous cell carcinoma Cal-27 cells [J]. , 2018, 38(6): 481-484.
[13]	. Clinical pathological significance of RPL29 in gingival squamous cell carcinoma [J]. , 2018, 38(6): 508-513.
[14]	. Expression and clinical significance of SUZ12 in tongue squamous cell carcinoma [J]. , 2018, 38(6): 499-502.
[15]	. Non-invasive Human Papilloma Virus Detection of Oral leukoplakia and Squamous Cell Carcinomas [J]. , 2018, 38(6): 528-532.