Abstract: Objective To study the significance of computed tomography (CT) in the diagnosis and treatment of severe neck multiple space infections. Methods A total of 10 patients with severe neck multiple space infections，admitted to the 252nd Hospital of PLA from January 2008 to December 2011,were investigated.Computed tomography scans of the neck were performed and the images were analyzed. Surgical incisions were planned based on the tomographic and clinical findings. Repeated CT examinations were also carried out in patients with no clinical improvement for additional drainage. Results Among the 10 patients,CT scans in 6 patients with necrotizing cellulitis demonstrated large quantities of gas along fascial planes and irregular jagged edge around the gas chamber. In another 4 patients with abscess,CT scans demonstrated diffuse swelling of muscles and solid tissues without clear boundary. Colliquativehypodensity region could be observed in the space. All the patients underwent surgical drainage. Low submandibular incision were performed in 2 patients,paralleled transcervical incisions in 5,and modified Crile incision in 3. 7 cases were saved successfully,3 patients died of multiorgans failure. The overall mortality rate is 30%. Conclusions CT scan is the first choice of imaging examination for correct evaluation of affected space in deep neck infections.Its main value lies in effectiveness in determining all the affected sites so as to provide basis for surgical incision,exposure and drainage of affected space.In the treatment,it′s important to perform CT reexamination according to illness state to estimate the control and development of the infection. A further incision should be performed when necessary. In addition,CT scan is auxiliary in initial evaluation of types of infected bacteria,illness state,and preliminary judgment of prognosis.