Abstract: Objective To evaluate the safety of articaine in cardiovascular patients with dental anxiety (DA) during tooth extraction according to the change of heart rate and blood pressure. Methods 152 cardiovascular patients with dental anxiety requiring tooth extraction were selected by Modified Dental Anxiety Scale (DAS),and they were randomly divided into articaine infiltrateanesthesia group and lidocaine blockanesthesia group.The blood pressure (BP) and heart rate (HR) were monitored by electrocardiogram monitor in the whole process of extraction,and then the differences of BP and HR between two groups were analyzed statistically. Results Tooth extraction in all patients was successfully completed.In the articaine group,systolic blood pressure,diastolic blood pressure and heart rate were significantly higher during anesthesia and tooth extraction than those of lidocaine group(P<0.01); The BP and HA in the articaine group showed no statistically significant difference from the data of lidocaine group before anesthesia and after tooth extraction (P>0.05). Conclusions In order to prevent cardiovascular and cerebrovascular accidents,articaine should be highly cautiously used in cardiovascular patients associated with dental anxiety during tooth extraction.