掺镁羟基磷灰石涂层对种植体骨结合的影响

Abstract

Abstract: Abstract： Objective To evaluate the effect of magnesium-substituted hydroxyapatite coating on peri-implant osseointegration using fluorescent microscope analysis. Methods 20 implants were separated into two groups equally.Ten implants in one group were coated with magnesium-ubstituted hydroxyapatite (Mg-HA); the other ten implants were coated with normal hydroxyapatite (HA) as control group.Both coatings were made using electrochemical deposition technology.All the implants were placed in the femur of adult rabbits.Oxytetracycline hydrochloride was given on the 7th day after operation,and alizarin-complexon was applied on the 28th day after operation,and calcein green was given on 46th day after operation.After 8 weeks,all the rabbits were sacrificed and all the samples collected from the femurs were observed with fluorescent microscope.The bone mineral apposition rate (MAR),bone area ratio (BAR) and bone to implant contact (BIC) were analyzed to indicate the difference of two types of implants.Results Peri-implant newly formed bone was observed in each group.From 7th to 53rd day after operation,the values of MAR and BAR in Mg-HA group were higher than those in HA group.However,no significant difference could be found (P>0.05).On 7th and 28th day,the BIC value of Mg-HA group was significantly higher than that of HA group (P＜0.05).Conclusions Compared with HA coating,Mg-HA coating could have more effect on enhancing peri-implant osseointegration.

Key words: implant, magnesium-substituted hydroxyapatite（Mg-HA）, hydroxyapatite（HA）, osseointegration

CLC Number:

R782.1

References

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Effects of magnesium ?ubstituted hydroxyapatite coating on implant osseointegration

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