Abstract: Objective To investigate the effects of changes of serum squamous cell carcinoma antigen(SCCAg) levels on prognosis of oral cavity squamous cell carcinoma.Methods The changes of serum SCCAg levels in oral cavity squamous cell carcinoma patients before and after operation were detected by ELISA.Results The incidences of recurrence or metastasis in patients whose serum SCCAg value <1.5 μg/L before and after operation were 15.6% and 3.1%; the incidences of recurrence or metastasis in patients whose serum SCCAg value >1.5 μg / L before and after operation were 83.3 percent and 95.5 percent; as for the patients whose preoperative serum SCCAg level >1.5 μg / L,their serum SCCAg levels fell and the postoperative SCCAg value <1.5 μg / L,and the recurrence or metastasis rate was 25%.Conclusions Serum SCCAg may be related to the development of oral squamous cell carcinoma,and the results can be used to evaluate the progress of the patient's conditions and the recurrence or metastasis of the tumor.

Key words: oral cavity squamous cell carcinoma, squamous cell carcinoma antigen, operation, prognosis