钛合金种植体表面生物活性因子缓释涂层的构建及生物学评价

Abstract

Abstract: Objective To explore the feasible way of constructing a bioactive factor release coating on the surface of titanium alloy implant and to investigate the bioactivity of a calcium/phosphorus/nerve growth factor composite coating constructed on the surface of titanium alloy implant. Methods Calcium/phosphorus/nerve growth factor composite coatings were prepared on the surface of titanium alloy implants using biomimetic deposition,and then characterized by Scanning Electron Microscope,and an automatic scratch tester.The total content of NGF in the composite coatings and the release value were measured every week by ELISA.The formation of calcified nodules was detected using a phase-contrast microscope. Results The coatings have rough surface,uniform and moderate thickness,and appropriate bonding strength.NGF can be released in vitro for at least 2 weeks,and remains active. Conclusions The calcium/phosphorus/nerve growth factor composite coatings prepared by biomimetic deposition can meet the demands of experimental research and clinical application.

Key words: Titanium, Implant, Osseointegration, Nerve growth factor, Composite coating

CLC Number:

R783.1

References

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The construction and biological evaluation of a bioactive factor release coating on the surface of titanium alloy implant

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