Abstract: Objective To investigate changes of the cytokine levels in the gingival crevicular fluid after applying force on the selfligating brackets and conventional brackets,and analyse the periodontal tissue remodeling.Methods Sixteen maxillary protruding patients who needed removing bilateral maxillary first premolars were selected,selfligating appliance being used on one side of the upper dentition as the experimental group,and using traditional straight wire appliance on the other side as the control group.IL1β and PGE2 levels of the gingival crevicular fluid taken at different time points in canine retraction were detected,and to analyze the relationship of their changes with periodontal tissue inflammatory response.Results After retruding the canines,levels of IL1β and PGE2 of the gingival crevicular fluid all increased and reached their top at 24 h.There were no significant differencesin IL1β and PGE2 levels of the gingival crevicular fluid between the experimental group and control group.Conclusions Selfligating appliance did not differ significantly from traditional appliance in periodontal tissue remodeling in the early phase of the orthodontic tooth movement.

Key words: self-ligating bracket, gingival crevicular fluid, IL-1β, PGE2, periodontal tissue