国内口腔鳞癌患者肿瘤组织中Cyclin D1表达的meta分析

Abstract

Abstract: Objective 　To explore Cyclin D1 expression in oral squamous cell carcinoma of Chinese people and its clinical significance.Methods 　The CNKI,CMCI,VIP,CBM,Wanfang databases were searched electronically. The literature concerning Cyclin D1 and domestic oral squamous cell carcinoma from 2000 to 2013 were included for Meta analysis. Results 　A total of 12 casecontrol studies were carried out,involving 629 cases of oral squamous cell carcinoma and 227 cases of normal oral mucosa. The metaanalysis results showed that the average positive expression rate of Cyclin D1 in oral squamous cell carcinoma of Chinese people was 69%,and the OR value was 20.51 with 95% confidence interval ［CI］12.50 to 33.66,P<0.000 01 ; Cyclin D1 was correlated with node metastasis (P<0.000 01) and clinical stage T (P=0.01) of oral squamous cell carcinoma lymph. Conclusions Cyclin D1 expression is related to the occurrence of oral squamous cell carcinoma of Chinese people,which can be considered as the auxiliary detection index in treatment of oral squamous cell carcinoma and its prognosis.

Key words: oral squamous cell carcinoma, Cyclin D1, meta-analysis

CLC Number:

R783.1

References

[1]Wang HC,Chiang WF,Huang HH,et al.Promoter hypermethylation of the gene encoding heat shock protein B1 in oral squamous carcinoma cells[J].Oral Surg Oral Med Oral Pathol Oral Radiol,2013,115(3):376-384
[2]〓Seto M.Cyclin D1negative mantle cell lymphoma［J］.Blood,2013,121(8),1249-1250.
[3]李光宇,毛雄辉,孙冀.Cyclin D1和中期因子在口腔鳞状细胞癌中表达的实验研究[J].口腔颌面外科杂志,2008,18(6):390-393
[4]曹雷,王莉红,刘婷娇.p27、cyclin D1蛋白和Ki67在口腔鳞癌中的表达及其意义[J].广西医学,2008,30(11):1655-1657
[5]李留炀,吴国英,杨筱荣.Stat3 、Bcl2及cyclin D1在口腔黏膜癌前病变癌变中表达的相关性研究[J].南京医科大学学报: 自然科学版,2011,31(9):1360-1368
[6]蔡传宝,陶学金,朱声荣,等.TGFβ1、 Smad4和 Cyclin Dl在口腔鳞癌中的表达和意义[J].口腔医学研究,2007,23(1):14-16
[7]王银龙,周洲,王元银,等.口腔鳞癌中Cyclin D1和Bcl2蛋白表达相关性的研究[J].安徽医药,2006,10(6):436-437
[8]陈中坚,邢树忠,江宏兵,等.口腔鳞癌中p16/CDK4/Cyclin D1/pRb通路的表达及其意义[J].口腔医学,2006,26(2):137-139
[9]何伟,陈卫民,廖建宏.口腔鳞癌组织中细胞周期蛋白D1和p27蛋白的表达[J].华北炭医学院学报,2010,12(2):141-143
[10]林耿冰,贾静,林李嵩,等.口腔鳞癌中 survivin 、Cyclin D1和p53基因的表达及其相性[J].细胞与分子免疫学杂志,2009,2 5(12):1194-1198
[11]朱东望,赵秀兰,李世芬.口腔鳞状细胞癌细胞周期因子p27、Cyclin Dl及CDK4的表达与意义[J].中国肿瘤临床,2003,30(1):40-44
[12]刘健,葛自力,惠建华,等.细胞周期素D1在口腔鳞癌组织中的表达及其意义[J].苏州大学学报:医学版,2009,29(2):328-329
[13]邢劲松,史培荣,陈显久,等.细胞周期素D1在口腔鳞状细胞癌组织中的表达及意义[J].华西口腔医学杂志,2011,29(3):200-305
[14]谢思明,沈丽佳,殷操,等.抑癌基因PTEN与PIP3、细胞周期蛋白D1在口腔鳞癌中的表达及其相关性分析[J].中华口腔医学杂志,2006,41(7):407-410
[15]Matsushime H,Roussel NF,Ashman RA,et al.Colony stimularing f actor regulates novel cyclin during the G1 phase of cell cycle[J].Cell,1991,65(4):701-713
[16]ggarwal P,Vaites LP,Kim JK,et al.Nclear cyclin D1/CDK4 kinase regulates CUI A expressionr and triggers neoplastic growth Via activation of the PRMT5 methyltrans ferase[J].Cancer Cell,2010,18(4):329-340
[17]Zhou CJ,Zhang QH,Zhang TG,et al.Expression of ER,Ki67 and cylin D1 in the precancerous breast of Chinese patients[J].Pathol Oncol Res,2009,15(2):153-158
[18]付志婕,潘新良,雷大鹏,等.细胞周期素 D1和 p16在下咽癌中的表达及临床意义[J].临床耳鼻喉头颈外科杂志,2007,21(9):406-409

Metaanalysis of the clinical and biological significance of Cyclin D1 expression in oral squamous cell carcinoma of Chinese

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