Neuropilin-1的结构、功能及其在口腔癌中研究进展

Abstract

Abstract: Neuropilin-1(NRP-1) is a transmembrane glycoprotein that acts as a co-receptor.And it is adjusted by miR - 9,miR - 124,miR - 181 - b,miR - 320,and it participates in the above cytokine signaling pathways,which is closely related with tumor angiogenesis and metastasis.Preliminary studies that show NRP-1 expression on T cells confers enhanced immunosuppressive activity.Some suggest a specific role for NRP-1 in cancer pathology.This article reviews current Knowledge on the structure and function of NRP-1,as well as its research status.

Key words: Neuropilin-1, oral cancer, therapeutic target

CLC Number:

R749.5

References

[1]Takagi S,Tsuji T,Amagai T,et al.Specific cell surface labels in the visual centers of Xenopus laevis tadpole identified using monoclonal antibodies[J].Dev Biol,1987,122(1):90-100
[2]Chaudhary B,Khaled YS,Ammori BJ,et al.Neuropilin 1: function and therapeutic potential in cancer[J].Cancer Immunol Immunother,2014,63(2):81-99
[3]Xu J,Xia J.NRP-1 silencing suppresses hepatocellular carcinoma cell growth in vitro and in vivo[J].Exp Ther Med,2013,5(1):150-154
[4]Rossignol M,Gagnon ML,Klagsbrun M.Genomic organization of human neuropilin-1 and neuropilin-2 genes: identification and distribution of splice variants and soluble isoforms[J].Genomics,2000,70(2):211-222
[5]Fantin A,Vieira JM,Plein A,et al.NRP1 acts cell autonomously in endothelium to promote tip cell function during sprouting angiogenesis[J].Blood,2013,121(12):2352-2362
[6]Kumanogoh A,Kikutani H.Immunological functions of the neuropilins and plexins as receptors for semaphorins[J].Nat Rev Immunol,2013,13(11):802-814
[7]Battaglia A,Buzzonetti A,Monego G,et al.Neuropilin-1 expression identifies a subset of regulatory T cells in human lymph nodes that is modulated by preoperative chemoradia-tion therapy in cervical cancer[J].Immunology,2008,123(1):129-138
[8]Herzog Y,Kalcheim C,Kahane N,et al.Differential expression of neuropilin-1 and neuropilin-2 in arteries and veins[J].Mech Dev,2001,109(1):115-119
[9]Pellet-Many C,Frankel P,Jia H,et al.Neuropilins: stucture,function and role in disease[J].Biochem J,2008,411(2):211-226
[10]Rizzolio S1,Rabinowicz N,Rainero E,et al.Neuropilin-1-dependent regulation of EGF-receptor signaling[J].Cancer Res,2012,72(22):5801-5811
[11]Ochsenbein AM,Karaman S,Jurisic G,et al.The Role of Neuropilin-1/Semaphorin 3A Signaling in Lymphatic Vessel Development and Maturation[J].Adv Anat Embryol Cell Biol,2014,214:143-152
[12]Tufro A.Semaphorin3a signaling,podocyte shape,and glomerular disease[J].Pediatr Nephrol,2014,29(4):751-755
[13]Fu L,Kitamura T,Iwabuchi K,et al.Interplay of neuropilin-1 and semaphorin 3A after partial hepatectomy in rats[J].World J Gastroenterol,2012,18(36):5034-5041
[14]Delgoffe GM,Woo SR,Turnis ME,et al.Stability and function of regulatory T cells is maintained by a neuropilin-1-semaphorin-4a axis[J].Nature,2013,501(7466):252-256
[15]Fantin A,Vieira JM,Plein A,et al.NRP1 acts cell autonomously in endothelium to promote tip cell function during sprouting angiogenesis[J].Blood,2013,121(12):2352-2362
[16]Fantin A,Herzog B,Mahmoud M,et al.Neuropilin-1 (NRP1) hypomorphism combined with defective VEGF-A binding reveals novel roles for NRP1 in developmental and pathological angiogenesis[J].Development,2014,141(3):556-562
[17]Lanahan A,Zhang X,Fantin A,et al.The neuropilin-1 cytoplasmic domain is required for VEGF-A-dependent arteriogenesis[J].Dev Cell,2013,25(2):156-168
[18]Vanveldhuizen PJ,Zulfiqar M,Banerjee S,et al.Differential expression of neuropilin-1 in malignant and benign prostatic stromal t5[J].Oncol Rep,2003,10(5):1067-1071
[19] Zhu H,Cai H,Tang M,et al.Neuropilin-1 is overexpressed in osteosarcoma and contributes to tumor progression and poor prognosis [J]. Clin Transl Oncol,2013,[Epub ahead of print]
[20]Barr MP,Byrne AM,Duffy AM,et al.A peptide corresponding to the neuropilin-1-binding site on VEGF(165) induces apoptosis of neuropilin-1-expressing breast tumour cells[J].Br J Cancer,2005,92(2):328-33
[21]Soker S,Takashima S,Miao HQ,et al.Neuropilin-1 is expressed by endothelial and tumor cells as an isoform-specific receptor for vascular endothelial growth factor[J].Cell,1998,92(6):735-745
[22]Ruffini F,D'Atri S,Lacal PM.Neuropilin-1 expression promotes invasiveness of melanoma cells through vascular endothelial growth factor receptor-2-dependent and -independent mechanisms[J].Int J Oncol,2013,43(1):297-306
[23]Neufeld G,Cohen T,Shraga N,et al.The neuropilins: multifunctional semaphorin and VEGF receptors that modulate axon guidance and angiogenesis[J].Trends Cardiovasc Med,2002,12(1):13-19
[24]Nasarre P,Kusy S,Constantin B,et al.Semaphorin SEMA3F has a repulsing activity on breast cancer cells and inhibits E-cadherin-mediated cell adhesion[J].Neoplasia,2005,7(2):180-189
[25]Starzec A,Vassy R,Martin A,et al.Antiangiogenic and antitumor activities of peptide inhibiting the vascular endothelial growth factor binding to neuropilin-1[J].Life Sci,2006,79(25):2370-2381
[26]Xu Y,Li P,Zhang X,et al.Prognostic implication of neuropilin-1 upregulation in human nasopharyngeal carcinoma[J].Diagn Pathol,2013,8:155-
[27]Piechnik A,Dmoszynska A,Omiotek M,et al.The VEGF receptor,neuropilin-1,represents a promising novel target for chronic lymphocytic leukemia patients[J].Int J Cancer,2013,133(6):1489-1496
[28]Bruder D,Probst-Kepper M,Westendorf AM,et al.Neuropilin-1: a surface marker of regulatory T cells[J].Eur J Immunol,2004,34(3):623-630
[29]Yadav M,Louvet C,Davini D,et al.Neuropilin-1 distinguishes natural and inducible regulatory T cells among regulatory T cell subsets in vivo[J].J Exp Med,2012,209(10):1713-22
[30]Campos-Mora M,Morales RA,Gajardo T,et al.Neuropilin-1 in Transplantation Tolerance[J].Front Immunol,2013,4:405-
[31]Tran DQ.TGF-β: the sword,the wand,and the shield of FOXP3(+) regulatory T cells[J].J Mol Cell Biol,2012,4(1):29-37
[32]Glinka Y,Stoilova S,Mohammed N,et al.Neuropilin-1 exerts co-receptor function for TGF-beta-1 on the membrane of cancer cells and enhances responses to both latent and active TGF-beta[J].Carcinogenesis,2011,32(4):613-621
[33]Yang H,Li M,Chai H,et al.Effects of cyclophilin A on cell proliferation and gene expressions in human vascular smooth muscle cells and endothelial cells[J].J Surg Res,2005,123(2):312-319
[34]Shimizu T,Jayawardana BC,Nishimoto H,et al.Hormonal regulation and differential expression of neuropilin (NRP)-1 and NRP-2 genes in bovine granulose cells[J].Reproduction,2006,131(3):555-559
[35]Lee RC,Feinbaum RL,Ambros V.The Celegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14[J].. Cell,1993,75(5):843-854
[36]Cui Y,Han Z,Hu Y,et al.MicroRNA-181b and microRNA-9 mediate arsenic-induced angiogenesis via NRP1[J].J Cell Physiol,2012,227(2):772-783
[37]Baudet ML,Zivraj KH,Abreu-Goodger C,et al.miR-124 acts through CoREST to control onset of Sema3A sensitivity in navigating retinal growth cones[J].Nat Neurosci,2011,15(1):29-38
[38]Wu YY,Chen YL,Jao YC,et al.miR-320 regulates tumor angiogenesis driven by vascular endothelial cells in oral cancer by silencing neuropilin 1[J].Angiogenesis,2014,17(1):247-260
[39]Zhang Y,He X,Liu Y,et al.microRNA-320a inhibits tumor invasion by targeting neuropilin 1 and is associated with liver metastasis in colorectal cancer[J].Oncol Rep,2012,27(3):685-694
[40]陈洁,张红闯,宋晓萌,等.Nrp-1、Nrp-2及SEMA3F在口腔癌组织及TCa、ACC细胞系中的表达及其可能的作用[J].口腔医学,2009,29(5):235-238
[41]蒋蕾,陈洁,张红闯,等.SEMA 3A及其受体Nrp-1及Plexin A1在口腔癌中的表达及其可能的作用[J].口腔医学,2009,29(11):564-567
[42]张阳,傅振,宋晓萌,等.Semaphorin 3A及其受体在舌鳞癌中的表达及作用[J].口腔生物医学,2011,2(1):21-25
[43]唐子春,王子露,刘来奎,等.Nrp-1在调控人舌鳞状细胞癌细胞分化中的作用[J].口腔医学研究,2012,28(6):601-604
[44]Song X,Zhang W,Zhang Y,et al.Expression of semaphorin 3A and neuropilin 1 with clinicopathological features and survival in human tongue cancer[J].Med Oral Patol Oral Cir Bucal,2012,17(6):e962-968

The structure,function of Neuropilin-1 and it′s research progress in oral cancer

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