Abstract: Objective To study the biological performance of the mineralized collagen coatings on titanium implant prepared by electrochemical deposition technique. Methods In this study, the electrochemical deposition technique was used to prepare the mineralized collagen coating on titanium surface, simulated body fluid (SBF) was used to characterize the HA-induced capacity, and MTS method was adopted to evaluate the adhesion and proliferation behaviors of the osteoblast cells. Results In vitro experimental results showed that the mineralized collagen coating was stable in simulated body fluid (SBF), and it could promote the adhesion, proliferation and differentiation of the osteoblast precursor cells. Conclusion Modification of the mineralized collagen coating on titanium implant surface can effectively promote its biological activity.

Key words: electrochemical deposition, mineralized collagen, titanium implant