miRNA-448在肿瘤中作用的研究进展

Abstract

Abstract: MicroRNA (miRNA) are highly conservative sequence of the coding protein widely existing in eukaryotic organism .The mature miRNA are 20~24 nucleotides, which can regulate a variety of cellular activities including proliferation, differentiation, and apoptosis. miRNA-448 can regulate adipocytes differentiation; it influences the accumulation of triglycerides and expression adipocytes, and also gets involved in the self-regulatory mechanisms of obesity. Moreover, it was found in a study that miRNA-448 could impact the immune response of the organism after microorganism infection through influencing the replication of hepatitis C virus. MiRNA-448 becomes a new biomarker due to its abnormal expression in the liver cancer、breast cancer、glioma and other tumors, and miRNA-448 is involved in cancer differentiation, invasion, transfer by the action of a plurality of target genes like STAB1、κB and5-HT2B . Recently we built a expression profile of miRNA and mRNA through a high-throughput deep sequencing technology in oral squamous cell carcinoma (OSCC) and found that miRNA-448 increased 10-fold compared to adjacent tissues and became the most elevated one in the hundreds of detected miRNA, so it may play an important role in OSCC. However, there is no research reporting miRNA-448 in OSCC yet. To enhance deep understanding of the role of miRNA-448 in OSCC, we are reviewing the progress of miRNA-448.

Key words: miRNA, oral squamous cell carcinoma, research progress

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References

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The research progress of functions of microRNA-448 in the tumor

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