AMD3100对口腔鳞状细胞癌细胞生物学行为的影响

Abstract

Abstract: 　Objective　 To investigate the effect of inhibition of CXCR4 antagonist AMD3100 on biological behavior of oral squamous cell carcinoma(OSCC) cells. Method MTT assay was used to evaluate AMD3100 influence on proliferation of tumor cells. Chemotaxis and migration response to inhibition of the specific CXCR4 antagonist AMD3100 was detected by chemotaxis assay. Results 1) In MTT assay, recombinant SDF-1 stimulated proliferation of tumor cells, and the availability of AMD3100 inhibited proliferation. 2) The chemotactic migration of OSCC cells could be induced by SDF-1. AMD3100 can inhibit the chemotaxis and invasion metastasis by blocking CXCR4 receptors. Conclusion The interaction of CXCR 4/SDF-1 system could be suppressed by AMD3100, and it can be a meaningful therapeutic target and strategy.

Key words: chemokine CXC motif receptor4, oral squamous cell carcinoma, AMD3100, proliferation, migration.

CLC Number:

R739.8，Q279

References

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Effects of inhibition of CXCR4 antagonist AMD3100 on biological behavior of oral squamous cell carcinoma

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