Abstract: Objective: This study evaluates a new collagen-based synthetic degradable barrier membrane for use in guided bone regeneration. Methods: A new collagen/HA-collagen degradable barrier membrane were embedded in Bama pigs mandibular bone and Bio-gide@ membrane served as reference materials. In Bama pigs, three standardized 8mm×8mm defect was created in mandibular bone. Three groups (collagen/HA-collagen，Bio-gide@, no membrane) were evaluated at 4 weeks. New bone formation was demonstrated by histological analysis. Results: In the Bio-gide@ and collagen/HA-collagen groups, the defects were left incompleted new formed bone filling. In contrast to uncovered mandibular defects, substantial bone healing was observed in defects covered with a barrier membrane. In the non membrane covered case, the formation of bone was unformed in 4 weeks. There were new formed bone under the Bio-gide@ and collagen/HA-collagen membranes. The amount of new bone formed under the Bio-gide@ membranes were more than the amount of bone formed under the collagen membranes. Conclusion: It can be concluded that the collagen/HA-collagen membrane was well suited for use in guided bone regeneration.

Key words: collagen membrane, guided bone regeneration (GBR), New bone formation