Abstract: Objective To detect the expressions of extracellular matrix metalloproteinase inducer(EMMPRIN) and its ligand cyclophilin A(CyPA) in peri-implant crevicular fluid (PICF) and provide scientific basics for future study on the role of EMMPRIN and CyPA in the pathogenesis and progression of peri-implantitis.Methods PICF of patients with prosthetic implants loading for more than one year (group IM) were collected and assayed for EMMPRIN and CyPA expressions by ELISA.The clinical periodontal status of these patients was examined.The relationships between the expressions of EMMPRIN and CyPA in PICF and clinical parameters together with the difference between group IM and the control group were analyzed. Results In group IM,there were significant positive correlations among PICF volume,EMMPRIN total amount and CyPA total amount.In addition,EMMPRIN total amount was positively correlated with gingival index(GI) and modified plaque index(mPLI),compared to the positive correlation between CyPA total amount and GI. Nevertheless,there was no significant difference between the two groups (P>0.05).Conclusions The expressions of EMMPRIN and CyPA in PICF,which were probably positively correlated with the inflammatory status of peri-implant tissues,were significantly positively correlated with PICF secretion.

Key words: extracellular matrix metalloproteinase inducer(EMMPRIN), cyclophilin A(CyPA), gingival crevicular fluid(GCF), peri-implant crevicular fluid(PICF)