生长激素对大鼠牙齿移动及牙周组织影响的研究

Abstract

Abstract: Abstract: Objective To investigate the effect of growth hormone (GH) on periodontal ligament,alveolar bone and orthodontic tooth movement in rats.Methods 40 Wistar rats (gender:male; age:7weeks) were randomly divided into control and experimental groups,each having 20 rats.The experimental group received subcutaneous injections of growth hormone at a dose of 0.15 IU/kg·d,and the control group received equivalent volumes of saline.A nickel titanium spring was fixed to maxillary incisors and the left upper first molar,with a force of 0.49N,so as to move the molar mesially.The rats were sacrificed on day 3,7,10 and 14.The distance of tooth movement was determined by using a vernier caliper.The sections of the maxillae were prepared for hematoxylineosin staining.Results On day 10 and 14,there was a significant difference of total tooth movement between the experimental group and the control group (P <0.05).Compared with the control group,the experimental group showed more osteoclasts on day 7 and more blood vessels on day 7 and 10.Conclusions Shortterm GH administration can affect bone remodeling and accelerate orthodontic tooth movement,shortening treatment time.

Key words: Keywords: Growth hormone, Tooth movement, Hematoxylin-eosin staining, Orthodontics

CLC Number:

R783.5

References

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The Effect of growth hormone on tooth movement and periodontal tissues of rats

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