Abstract: Abstract: Objective To observe the therapeutic effects of marsupialization and orthodontic traction on the treatment of dentigerous cyst in mixed dentition stage．Methods Twelve cases of dentigerous cysts in mixed dentition stage were treated at the Affiliated Hospital of Stomatology,Nanjing Medical University from 2007 to 2012 with marsupialization of the cysts to preserve permanent tooth buds,then obturators were used to guarantee the effective draining and maintain the teeth space,and further orthodontic treatment was carried out to ensure the normal eruption of the involved teeth.The patients were followed up for 2~3 years after marsupialization,and the bone tissue healing and permanent teeth eruption were observed.Results After the therapy of marsupialization and further treatment of orthodontic traction for 12~15 months,permanent teeth which were involved in the cysts of all the 12 patients erupted totally and dental arrangement was kept in alignment.Patients′ facial morphology returned to normal,and the lowdensity shadow of cyst cavity disappeared according to imageological examination.No cyst recurrence was observed during the following up for more than 2 years postoperatively.Conclusions Marsupialization and further orthodontic treatment is an effective treatment of dentigerous cysts in mixed dentition stage,which could retain the involved teeth and bone tissue to the maximum degree.