Abstract: Objective To estimate the efficacy and safety of oral propranolol in treatment of infantile hemangioma. Methods From Mar., 2012 to Mar., 2014, 49 children with infantile hemangioma were selected as experiment group by using propranolol at a dose of 2.0 mg/(kg?d-1), twice a day; 40 children with infantile hemangioma were selected as control group by undergoing intralesional injection with pingyangmycin. The changes of the hemangioma size and the incidence of adverse reactions were recorded every 3 to 4 weeks. The entire process lasted until the lesion did not change. Efficacy was evaluated by using Achauer system. Results In propranolol group, the total effective rate was 93.88%, including 3 cases of classⅠ(poor), 6 cases of classⅡ(moderate), 16 cases of classⅢ(good), and 24 cases of classⅣ(excellent); In pingyangmycin group, the total effective rate was 77.50%, including 9 cases of classⅠ(poor), 11 cases of classⅡ(moderate), 13 cases of classⅢ(good), and 7 cases of classⅣ(excellent). The efficacy in propranolol group was significantly better than that in pingyangmycin group (P＜0.05). The incidence of adverse reactions in propranolol group (6.12%) was lower than that in pingyangmycin group (10.00%). Conclusion Oral propranolol is effective in treatment of infantile hemangioma, with a low incidence of adverse reactions.

Key words: hemangioma, propranolol, pingyangmycin