›› 2016, Vol. 36 ›› Issue (10): 870-875.

• Basic Research • Previous Articles     Next Articles

Influence of over expression of DMP1 in Nestin positive cells on the changes of jaw bone density in mice

PAN Min,   

  • Received:2016-05-30 Revised:2016-07-05 Online:2016-10-28 Published:2016-10-25

Abstract: Objective To discuss the role of dental matrix protein 1(DMP1) in Nestin(+) cells. Methods DMP1 is an important mineralization protein of teeth and bones, but the role of DMP1 in Nestin(+) cells is still not clear. A transgenic mouse model was constructed in which DMP1 over expressed in Nestin(+) cells. With wild mice as the control group, the DMP1-Tg mouse’s jaw phenotypes by H&E staining and micro-CT were observed. Besides, the change of bone resorption in DMP1-Tg mouse by TRAP staining was also observed. Results Compared with WT mouse, the mandibular bone mass of DMP1-Tg mouse decreased; TRAP staining showed increased number of osteoclasts in DMP1-Tg mouse. Conclusion During the process of jaw development, the over expression of DMP1 in Nestin(+) cell can inhibit osteogenesis.

Key words: Nestin, Dental matrix protein 1, Jaw bone

CLC Number: