Abstract: Purpose To evaluate the root canal treatment reaction and long-term efficacy of three different root canal sealers.Methods 163 cases of teeth with a total of 179 were randomized into three groups:group A,including 60 teeth,treated with iRoot SP sealer;group B,including 60 teeth,treated with AH Plus sealer;group C,including 59 teeth,treated with Iodoform sealer;The different incidence of postoperative pain and the one-year successful rate were observed.Data were analyzed using SPSS13.0 software.Results Three kinds of root canal sealer incidence of pain after 7 d: group A was lower than group B and group C（P＜0.05）。compared the one-year successful rate: group A＞ group C and group B ＞group C（P＜0.05）。There were no significant difference between group A and group B（P＞0.05）。Conclusion The iRoot SP sealer was better than the AH Plus sealer and iodoform sealer in single visit root canal treatment,which was an ideal root canal sealer.

Key words: single visit root canal treatment, root canal sealer, root canal filling, iRoot SP, AH Plus