Abstract: Obejetive To explore the expression of TNF-α, BAFF, ICAM-1 and VCAM-1 in the serum of patients with primary Sjgeren’s syndrome and to provide experimental basis for clinical treatment of pSS. Methods Fifty primary Sjgeren’s syndrome patients were diagnosed by pathological examination. Serum expression levels of TNF-α, BAFF, ICAM-1 and VCAM-1 were detected by enzyme linked immunosorbent assay (ELISA). The software SPSS was used for statistical analysis. Results The expression levels of TNF-α, BAFF, ICAM-1 and VCAM-1 obviously increased in serum of pSS patients compared with healthy subjects (P<0.05). Conclusion TNF-α, BAFF, ICAM-1 and VCAM-1 may be involved in the occurrence and development of pSS, and the exact interactions between them still need further research.

Key words: Sjgeren’s syndrome, TNF-α, BAFF, ICAM-1, VCAM-1