Abstract: Objective To assess the clinical efficacy of strontium doped bioactive gel(Camgna densensitezer) combined with pulsed Nd: YAG laser on the treatment of dentin hypersensitivity. Methods 156 teeth of 89 cases with dentin hypersensitivity were divided into three groups randomly，and treated with three different desensitization therapies as bioactive glass combined with Nd: YAG laser(52), Nd:YAG laser(control A:49) and Camgna densensitezer(control B:55) respectively.Effectiveness of the three agents on dentin hypersensitivity was examined immediately，one month and three months after the treatment. Result No statistically significant differences appeared in VAS score among three experimental groups after treatment(P>0.05). The effectiveness of the experimental and control groups was similar immediately after the treatment，but significantly higher than laser(A) and Camgna densensitezer group(B)(P＜0.05). The effectiveness of all the agents reduced one or three months later，and experimental group showed better effectiveness than laser and Camgna densensitezer group(P＜0.05，P＜0.01). Conclusion Camgna densensitezer combined with pulsed Nd: YAG laser is an effective desensitizer for dentin hypersensitivity.

Key words: Pulsed Nd:YAG laser, strontium doped bioactive gel(Camgna), Dentin hypersensitivity