Abstract: Abstract: The bioactive glass (BG) is a kind of biomaterial based on CaO-SiO2-P2O5 composition, which has excellent bioactivity, biocompatibility, osteoconductivity and antibacterial properties. It has been widely applied in bone tissue engineering, plastic surgery, dentistry and other fields. BG has good antibacterial property not only for common pathogenic bacteria such as S. aureus, E. coli and P.aeruginosa, but also for some oral bacterium of aerobic and anaerobic bacteria such as S.sanguis, Aa and P. gingivalis. The mesoporous Bioactive Glass (MBG) is a new type of BG, which possesses a highly ordered mesoporous channel, higher specific surface area and pore volume, better biocompatibility, osteoconductivity and osteogenesis. The unique mesoporous structure of MBG can deliver antibacterial agents or metal ions, which releases slowly and gives play to long-term antibacterial effects.

Key words: bioactive glasses, antibacterial, root canal infection