药物诱发性天疱疮

Abstract

Abstract: Drug-induced pemphigus is a special type of pemphigus. In those cases, the disease is generally mild and will accelerate or relapse after taking the culprit drug again. The drugs have been proved to play a definite role in the pathogenesis of those patients. According currently reports, the number of DIP cases and the types of drugs are increasing, including thiol drugs and nonthiol drugs. In most of studies, researchers consider that its pathogenesis relates to genetic and the culprit drug, and the culprit drug includes both biochemical and immunologic. The clinical manifestations are not specific, relating to the type of drug, and mainly show foliaceus variety and vulgaris variety. New auxiliary diagnostic method (in vitro interferon-gamma release test) has been used to determine the culprit drug and provides an important reference. 32-2B mucosal immunostaining provides important information for the diagnosis and prognosis of drug-induced pemphigus.

Key words: Drug-induced pemphigus, thiol/nonthiol drugs, In vitro interferon-gamma release test, 32-2B mucosal immunostaining

References

参考文献 [1] Brenner S, Bialy-Golan A, Ruocco V. Drug-induced pemphigus[J]. Clin Dermatol, 1998,16(3):393-397. [2] Brenner S, Goldberg I. Drug-induced pemphigus[J]. Clin Dermatol, 2011,29(4):455-457. DOI: 10.1016/j.clindermatol.2011.01.016. [3] Brenner S, Bialy-Golan A, Anhalt GJ. Recognition of pemphigus antigens in drug-induced pemphigus vulgaris and pemphigus foliaceus[J]. J Am Acad Dermatol, 1997,36(6 Pt 1):919-923. [4] Yoshimura K, Ishii N, Hamada T, et al. Clinical and immunological profiles in 17 Japanese patients with drug-induced pemphigus studied at Kurume University[J]. Br J Dermatol, 2014,171(3):544-553. DOI: 10.1111/bjd.12925. [5] 冯素英, 林麟, 靳培英. 药物诱发天疱疮[J].中华皮肤科杂志,2007,(11):712-715. 2007,(11):712-715. [6] Korman NJ, Eyre RW, Zone J, et al. Drug-induced pemphigus: autoantibodies directed against the pemphigus antigen complexes are present in penicillamine and captopril-induced pemphigus[J]. J Invest Dermatol, 1991,96(2):273-276. [7] Ruocco V, De Angelis E, Lombardi ML. Drug-induced pemphigus. II. Pathomechanisms and experimental investigations[J]. Clin Dermatol, 1993,11(4):507-513. [8] Pe?as PF, Buezo GF, Carvajal I, et al. D-penicillamine-induced pemphigus foliaceus with autoantibodies to desmoglein-1 in a patient with mixed connective tissue disease[J]. J Am Acad Dermatol, 1997,37(1):121-123. [9] Gholizadeh N, Taghavi ZA, Eslami H. Pemphigus Vulgaris Associated with Rheumatoid Arthritis in a Patient not Taking Penicillamine[J]. J Dent Res Dent Clin Dent Prospects, 2012,6(1):33-35. DOI: 10.5681/joddd.2012.008. [10] Ong CS, Cook N, Lee S. Drug-related pemphigus and angiotensin converting enzyme inhibitors[J]. Australas J Dermatol, 2000,41(4):242-246. [11] 张学军, 翁孟武. 药物诱导天疱疮的机理[J].中国药理学通报,1993,(05):339-341. 1993,(05):339-341. [12] 陈泽仪. 青霉胺诱发天疱疮[J].国外医学参考资料.皮肤病学分册,1977,(03):167. 1977,(03):167. [13] Goldberg I, Shirazi I, Brenner S. In vitro interferon-gamma release test in patients with drug-induced pemphigus[J]. Isr Med Assoc J, 2008,10(6):424-427. [14] Goldberg I, Kashman Y, Brenner S. The induction of pemphigus by phenol drugs[J]. Int J Dermatol, 1999,38(12):888-892. [15] Tang X, Zhang X. Drug-induced pemphigus after six years of treatment with phenytoin and carbamazepine[J]. Int J Dermatol, 2012,51(4):485-486. DOI: 10.1111/j.1365-4632.2010.04706.x. [16] Baroni A, Russo T, Faccenda F, et al. Amoxicillin/clavulanic acid-induced pemphigus vulgaris: case report[J]. Acta Dermatovenerol Croat, 2012,20(2):108-111. [17] Bauza A, Del PLJ, Saus C, et al. Pemphigus-like lesions induced by imiquimod[J]. Clin Exp Dermatol, 2009,34(5):e60-62. DOI: 10.1111/j.1365-2230.2008.03181.x. [18] Sebaratnam DF, Martin LK, Rubin AI, et al. Reversible relapse of pemphigus foliaceus triggered by topical imiquimod suggests that Toll-like receptor 7 inhibitors may be useful treatments for pemphigus[J]. Clin Exp Dermatol, 2011,36(1):91-93. DOI: 10.1111/j.1365-2230.2010.03918.x. [19] Anadolu RY, Birol A, Bostanci S, et al. A case of pemphigus vulgaris possibly triggered by quinolones[J]. J Eur Acad Dermatol Venereol, 2002,16(2):152-153. [20] Ghaffarpour G, Jalali MH, Yaghmaii B, et al. Chloroquine/hydroxychloroquine-induced pemphigus[J]. Int J Dermatol, 2006,45(10):1261-1263. DOI: 10.1111/j.1365-4632.2006.03075.x. [21] Yanagishita T, Tamada Y, Watanabe D. Bucillamine-induced pemphigus vulgaris[J]. J Eur Acad Dermatol Venereol, 2015,29(6):1242-1243. DOI: 10.1111/jdv.12472. [22] Feldmann R, Loader DE, Otruba T, et al. Non-drug-induced pemphigus foliaceus in a patient with rheumatoid arthritis[J]. Cutis, 2016,97(3):E1-2. [23] Brenner S, Srebrnik A, Goldberg I. Pemphigus can be induced by topical phenol as well as by foods and drugs that contain phenols or thiols[J]. J Cosmet Dermatol, 2003,2(3-4):161-165. DOI: 10.1111/j.1473-2130.2004.00098.x. [24] Goldberg I, Sasson A, Gat A, et al. Pemphigus vulgaris triggered by glibenclamide and cilazapril[J]. Acta Dermatovenerol Croat, 2005,13(3):153-155. [25] Newby CS, Barr RM, Greaves MW, et al. Cytokine release and cytotoxicity in human keratinocytes and fibroblasts induced by phenols and sodium dodecyl sulfate[J]. J Invest Dermatol, 2000,115(2):292-298. DOI: 10.1046/j.1523-1747.2000.00056.x. [26] Pietkiewicz P, Gornowicz-Porowska J, Bowszyc-Dmochowska M, et al. A retrospective study of antihypertensives in pemphigus: a still unchartered odyssey particularly between thiols, amides and phenols[J]. Arch Med Sci, 2015,11(5):1021-1027. DOI: 10.5114/aoms.2015.54857. [27] Ong CS, Cook N, Lee S. Drug-related pemphigus and angiotensin converting enzyme inhibitors[J]. Australas J Dermatol, 2000,41(4):242-246. [28] Amagai M, Tanikawa A, Shimizu T, et al. Japanese guidelines for the management of pemphigus[J]. J Dermatol, 2014,41(6):471-486. DOI: 10.1111/1346-8138.12486. [29] Hertl M, Jedlickova H, Karpati S, et al. Pemphigus. S2 Guideline for diagnosis and treatment--guided by the European Dermatology Forum (EDF) in cooperation with the European Academy of Dermatology and Venereology (EADV)[J]. J Eur Acad Dermatol Venereol, 2015,29(3):405-414. DOI: 10.1111/jdv.12772. [30] Maruani A, Machet MC, Carlotti A, et al. Immunostaining with antibodies to desmoglein provides the diagnosis of drug-induced pemphigus and allows prediction of outcome[J]. Am J Clin Pathol, 2008,130(3):369-374. DOI: 10.1309/3CAKPEU8JXGWLEDC. [31] Feng S, Zhou W, Zhang J, et al. Analysis of 6 cases of drug-induced pemphigus[J]. Eur J Dermatol, 2011,21(5):696-699. DOI: 10.1684/ejd.2011.1428. [32] Goldberg I, Hanson M, Chodick G, et al. In vitro release of interferon-gamma from peripheral blood lymphocytes in cutaneous adverse drug reactions[J]. Clin Dev Immunol, 2012,2012:687532. DOI: 10.1155/2012/687532. [33] Burge SM, Wilson CL, Dean D, et al. An immunohistological study of desmosomal components in pemphigus[J]. Br J Dermatol, 1993,128(4):363-370. [34] Sugita K, Hirokawa H, Izu K, et al. D-penicillamine-induced pemphigus successfully treated with combination therapy of mizoribine and prednisolone[J]. J Dermatolog Treat, 2004,15(4):214-217. DOI: 10.1080/09546630410027805. [35] Tóth GG, Jonkman MF. Successful treatment of recalcitrant penicillamine-induced pemphigus foliaceus by low-dose intravenous immunoglobulins[J]. Br J Dermatol, 1999,141(3):583-585. [36] Khashoggi M, Machet L, Perrinaud A, et al. [D-penicillamine-induced pemphigus: changes in anti-32-2B immunostaining patterns][J]. Ann Dermatol Venereol, 2013,140(8-9):531-534. DOI: 10.1016/j.annder.2013.04.073.

Drug-induced pemphigus

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