›› 2017, Vol. 37 ›› Issue (5): 403-407.

• Basic Research • Previous Articles     Next Articles

The role of blocking of FZD3 and MAPK10 with EGCG in the treatment of jaw keratocystic odontogenic tumor

  

  • Received:2016-10-21 Revised:2017-02-05 Online:2017-05-28 Published:2017-05-19

Abstract: Objective To study the role of epigallocatechin-3-gallate(EGCG), the inhibitor of Wnt signaling pathway, in the marsupialization treatment of jaw keratocystic odontogenic tumor(KCOT). Methods Twenty-five specimens of KCOT were obtained, twenty before marsupialization, five after marsupialization, three treated with EGCG solution and two with normal saline(NS). The expressions of FZD3 and MAPK10, Wnt signaling pathway genes, were detected. The normal oral mucosa of the same patient was as control. Result Compared to normal oral mucosa, the expressions of FZD3 and MAPK10 in KCOT were up-regulated, which decreased after the treatment of marsupialization with normal saline, but were still higher than those of normal oral mucosa. However, the expressions of FZD3 and MAPK10 in KCOT sharply decreased after the treatment with EGCG and were similar to normal oral mucosa. Conclusion FZD3 and MAPK10 genes are over-expressed in KCOT. Marsupialization with EGCG can block the expressions of FZD3 and MAPK10, which play a role in the treatment of jaw KCOT.

Key words: Epigallocatechin-3-gallate, Keratocystic odontogenic tumors, Wnt signaling pathway

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