缺氧环境下LPS诱导人牙周膜成纤维细胞炎性损伤的研究进展

›› 2017, Vol. 37 ›› Issue (5): 449-452.

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Research progress of inflammatory injury in human periodontal ligament cells induced by LPS under hypoxia

Received:2016-11-22 Revised:2016-12-20 Online:2017-05-28 Published:2017-05-19

Abstract

Abstract: Lipopolysaccharide(LPS)，which is one of the main virulence factors of periodontitis, results in the inflammatory injury of human periodontal ligament cells (hPDLCs) directly or indirectly. However, hPDLCs reside in a inflamed and hypoxic microenvironment due to their special location. Thus, simulating the inflammatory microenvironment of hPDLCs in vivo will be beneficial to clarifying the mechanism of periodontitis. In this paper, research on the inflammatory injury in hPDLCs induced by LPS under hypoxia will be entensively reviewed.

Key words: hypoxia, LPS, periodontitis

CLC Number:

R780.2

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Research progress of inflammatory injury in human periodontal ligament cells induced by LPS under hypoxia

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