Abstract: Abstract ：Objective: analysis of the effect of fluoride protector joint fissure sealants on the prevention of the first molar caries; Methods:1,200 teeth of 300 aged 6-8 children were included in this research and were just given pit and fissure sealant or combine fluor protector with self control method. The retention of pit and fissure sealant, caries incidence rate and caries prevalence rate were observed and analyzed at 6,12,18,24 months. Results ：The results showed that test group has a higher retention of pit and fissure sealant and lower caries incidence rate than control group at each time. After analysis,it were found that the caries incidence rate in 12,18months and the caries prevalence rate in 2years have statistically significant (P <0.05). Compared to control group,the caries reduction rate of the test group is 61.3% after 2years.Conclusion: This research suggest that pit and fissure sealant combine with fluor protector could have better curies prevention effect than pit and fissure sealant single.

Key words: fluoride protector, fissure sealants, the first molar