Abstract: Objective: to design a model perfusion frame for orthodontic study model based on the data of malocclusal patients, Methods: randomly selected 200 models of malocclusion from the patients of Guangxi Medical University since 2014 to 2015, use the 1:1 fixed focus camera to take the image of upper occlusal surface of the choosed models, use Photoshop CS6 software to measure and calculate the corresponding length of the study model' s bottom edge, use vernier caliper to measure the distance between the bottom of the canine vestibular groove. Based on the statistical analysis of the measured data model, design a model rubber base whose size is suitable for clinical application , and a height adjustable model perfusion frame has been designed too. Results: malocclusion deformity patients with dental arch size data, whereby the design of the rubber base is more suitable for making orthodontic study model. In addition, the design of the model perfusion frame can provide a stable support and accurate positioning in the process model perfusion. Conclusion: the frame for study model making can improve the efficiency and quality of model preparation in clinic, and reduce the waste of hydroelectric resources. It has a good clinical application prospect.