›› 2018, Vol. 38 ›› Issue (4): 372-375.

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Research progress on animal models of osteoradionecrosis of jaws

  

  • Received:2017-07-21 Revised:2017-08-16 Online:2018-04-28 Published:2018-05-03
  • Contact: li jie E-mail:15862203588@163.com

Abstract: Osteoradionecrosis of jaws (ORNJ) is one of the most severe complications following radiotherapy for patients with head and neck cancer. ORNJ develops slowly and has long duration of illness. The pathogenesis and pathophysiology of ORNJ still remain unclear. Due to the lack of effective therapeutics, this disease has long been a difficult clinical problem. It’s meaningful to establish animal models of ORNJ for exploring its pathogenesis, disease prevention and therapeutic intervention. This review introduces and summarizes the animal choice, building methods, evaluation indicators and application of ORNJ model.

Key words: osteoradionecrosis of jaws, animal models, irradiation

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