Abstract: Oral mucosal diseases pose a threat to human health and quality of life. The etiology of most of oral mucosa diseases is unknown, so it’s difficult for clinical work and research. To explore the pathogenesis and prevention measures of oral mucosa diseases, how to establish animal models of oral mucosal diseases is particularly important. For how to establish mucosal disease animal models of specific mucosal diseases, such as oral ulcer, oral leukoplakia and oral carcinoma , there are detailed introductions at home and abroad, but the conclusive papers and literature are comparatively rare. Thus, some mature animal models of oral mucosa diseases will be introduced in detail in this paper.

Key words: Oral mucosal diseases , Animal , Models