Abstract: Chronic periodontitis (CP) is a chronic inflammatory disease characterized by periodontal soft and hard tissue destruction, and the local inflammatory microenvironment runs through all stages of lesions. At present, the common diagnostic criteria for CP include periodontal probing depth, bleeding on probing and evaluation of alveolar bone level by radiographic examination, but there is a lack of accurate assessment of the inflammatory state and the definition of periodontal disease progression. It has been a research hotspot worldwide that how the biomarkers come into wide use to conduct rapid and accurate screening, provide accurate detection information and reliably assess the disease state of CP. Gingival crevicular fluid (GCF) is a serum or inflammatory exudate from periodontium. Its biomarkers are closely related to inflammation and destruction of connective tissue and bone tissue, so they are used to assess the lesions and the evaluation of the therapeutic effect. Thus, this paper reviews the diagnostic value and research progress of GCF biomarkers before and after nonsurgical therapy of CP.

Key words: Chronic periodontitis, biomarkers, gingival crevicular fluid, nonsurgical periodontal therapy