›› 2019, Vol. 39 ›› Issue (12): 1062-1067.

• Basic Research • Previous Articles     Next Articles

The effect of micro arc oxidation treated Ti surface on osteogenic differentiation of bone marrow mesenchymal stem cells and osseointegration of induced type 2 diabetes mellitus rats.

  

  • Received:2018-07-27 Revised:2018-11-23 Online:2019-12-28 Published:2019-12-31

Abstract: Objective: The aim of the study was to evaluate the effect of micro arc oxidation treated Ti surface on osteogenic differentiation of bone marrow mesenchymal stem cells and osseointegration of induced type 2 diabetes mellitus rats. Materials and methods. TC4 surface was treated by micro arc oxidation to create a hierarchy structure. Type 2 diabetic rat model was induced by feeding with high-fat diet and followed by injection of streptozotocin. The BMSCs of diabetic rat were cultured in vitro. The cells were seeded on the treated surface to evaluate the effect of the surface on osteogenic differentiation. The implant with the surface was inserted in the diabetic rats’ femurs to evaluate the influence on new bone formation and bone implant contact. Results. In vitro study revealed the treated structure could upregulate the expressions of osteogenic-related markers. In vivo study revealed the enhanced bone regeneration, implant bone contact in diabetic rats. Conclusions. The advantages of micro arc oxidation treated surface could improve osteogenic differentiation and osseointegration in diabetic environment.

Key words: micro-oxidation, type 2 diabetes ,osteogenic differentiation, osseointegration