丹参素在体外条件下对口腔鳞癌细胞  CAL-27抑制作用的研究

Abstract

Abstract: Abstract： Objective To investigate the effects of Danshensu on the proliferation, migration and invasion of oral squamous cell carcinoma CAL-27 in vitro. Methods Danshensu was used to treat CAL-27 cells, and the effect of Danshensu on the activity of CAL-27 cells were detected by MTT assay. The scratch test determined the effect of Danshensu on the migration ability of CAL-27 cells. The transwell assay inspected its effect on the invasive ability of cells.Results MTT showed that Danshensu inhibited the proliferation of CAL-27 cells in a dose- and time-dependent manner at concentrations of Danshensu at 40 μg/mL, 60 μg/mL and 80 μg/mL. In the scratch test, the difference between the 24h group and the control group was statistically significant. (P<0.01). The results of Transwell invasion assay showed that Danshensu can reduce the invasive ability of CAL-27 cells. Conclusion In vitro ,danshensu inhibits the proliferation of CAL-27 cells and reduces the migration and invasion of CAL-27 cells.

Key words: Danshensu, oral squamous cell carcinoma, proliferation, migration, invasion

CLC Number:

R739.8

References

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Inhibitory effect of danshensu on oral squamous cell carcinoma CAL-27 cells in vitro

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