| [1]周东学，施文元. 微生物生物膜与感染[M].人民卫生出版社. 2012,4.[2]Wunder DB, Bosscher VA, Cok RC,Hozalski RM. Sorption of antibiotics to biofilm[J]. Water Res,2010, 45(6):2270-80.[3]曹采方. 临床牙周病学[M]. 北京大学医学出版社. 2008, 1.[4]X.L.Luan, Y.L.Qin, L.J.B, et al. Histological evaluation of the safety of toluidine blue-mediated photosensitization to periodontal tissues in mice[J].Lasers Med Sci,2009, 24(2):162-166.[5]王静,王志刚,许川山. 声动力疗法医学应用及其生物学效应[M]. 中国医学影像术，2006，22(12):1918-1921.[6]Ma X, Pan H, Wu G, et al. Ultrasound may be exploited for the treatment of microbial diseases[J]. Med Hypotheses,2009, 73(1):18-9.[7]Wu X, Joyce EM, Mason TJ. Evaluation of the mechanisms of the effect of ultrasound on Microcystis aeruginosa at different ultrasonic frequencies[J]. Water Res,2012, 46(9):2851-8.[8]于丽，李晓原. 第二代光敏剂血卟啉单甲醚及其临床应用研究进展[J].生物医学工程与临床.2005,9(6)：365-368.[9]郭芳，胡兵.低频超声的应用基础研究进展[J].声学技术.2012,31(2):198-203.[10]Asano J, Suisha F, Takada M, et al. Effect of pulsed output ultrasound on the transdermal absorption of indomethacin from an ointment in rats[J]. Biol Pharm Bull, 1997, 20(3): 288.[11]Boucaud A. Clinical, histologic and electron microscopy study of skin exposed to low-frequency ultrasound[J]. The Anatomical Record, 2001, 264(1): 114-119.[12]Vesna Zderic, Shahram Vaezy, Roy W, et al. Ocular drug delivery using 20- kHz ultrasound[J]. Ultrasound in Medicine& Biology,2002, 28(6): 823.[13]Poliachik SL, Chandler WL, Mourad, et al. Activation, aggregation and adhesion of platelets exposed to high- intensity focused ultrasound[J]. Ultrasound Med Biol, 2001, 27(11): 1567.[14]屠熙，尹芹芹，张文胜.低频超声透皮给药的研究进展与应用[J].生物医学工程学杂志 ，2008,25(6):1474-1478.[15]Funke AP, Gunther C, Muller RH, et al. In- vitro release and transdermal fluxes of a highly lipophilic drug and of enhancers from matrix TDS[J]. J Control Release, 2002, 82(1): 63.[16]Frenkel V, Kimmel E, Iger Y, et al. Ultrasound- induced inter-cellular space widening in fish epidermis[J]. Ultrasound Med Biol,2000, 26(3): 473.[17]Polat BE, Figueroa PL, Blankschtein D, et al. Transport pathways and enhancement mechanisms within localized and non-localized transport regions in skin treated with low-frequency sonophoresis and sodium lauryl sulfate[J]. Journal of Pharmaceutical Sciences, 2011, 100(2): 512-529.[18]Polat BE, Deen WM, Langer R, et al. A physical mechanism to explain the delivery of chemical penetrationenhancers into skin during transdermal sonophoresis-insight into the observed synergism[J]. Controlled Release 2012,158:250-260.[19]Lenart I. The effect of ultrasound on diffusion through membranes[J]. Ultrasonics, 1980, 18(5): 216-218.[20]Mitragotri S, Farrell J, Tang H, et al. Determination of threshold energy dose for ultrasound- induced transdermal drug transport[J]. J Control Release, 2000, 63(1- 2): 41.[21]Tachibana K, Tachibana S. The use of ultrasound for drug delivery[J]. Echocardiography, 2001, 18(4): 323.[22]Simonin J P. On the mechanisms of in vitro and in vivo phonophoresis[J]. Journal of Controlled Release, 1995, 33(1): 125-141.[23] Costerton JW, Stewart PS, Greenberg EP. Bacterial biofilms: a common cause of persistent infections [J]. Science, 1999, 284(5418):1318-1322.[24]Coenye T, Nelis HJ. In vitro and in vivo model systems to study microbial biofilm formation [J]. Journal of microbiological methods,2010, 83(2): 89-105.[25]陈磊.低频超声透皮给药的作用机制和影响因素[J].科技视界.2016,(17):241+265.[26]ShozoMiyazaki, YumiKokata, MasahikoTakada. Effect of ultrasound on transdermal absorption of in domethcin-continuous mode and pulse mode[J]. Yaluzaigaku, 1992,52(4): 264-268.[27]蒋治楠，王涛，汪滢，等. 低频超声对金黄色葡萄球菌生物膜的促渗作用研究[J]. 现代生物医学进展.2016,16(14):2618-2623。[28]Runyan CM, Carmen JC, Beckstead BL, et al. Low-frequency ultrasound increases outer membrane permeability of Pseudomonas aeruginosa [J]. The Journal of general and applied microbiology,2006, 52(5): 295-301。[29]徐杰，庄万强，斯海波，等.低频超声联合抗生素对表皮葡萄球菌生物膜渗透性的影响[J].中国抗生素杂志,2014,5(39):390-393.[30]Sousa C, Teixeira P, Oliveira R. The role of extracellular polymers on Staphylococcus epidermidis biofilm biomass and metabolic activity[J]. J Basic Microbiol, 2009,49(4): 363-370.[31]Hernot S, Klibanov A L. Microbubbles in ultrasoundtriggered drug and gene delivery[J]. Adv Drug Deliv Rev, 2008, 60(10): 1153-1166.[32]Pitt W G, Husseini G A, Staples B J. Ultrasonic drug delivery-a general review[J]. Expert Opin Drug Deliv, 2004, 1(1): 37-56.[33]朱晨，方诗元，孔荣，等. 超声靶向微泡破坏增强人β-防御素 3 抑制小鼠体内耐药葡萄球菌生物膜形成[J].生物骨科材料与临床研究,2015,12(5):8-12.[34] Li F, Wu W, Xiang L, et al. Sustained release of VH and rh BMP-2 from nanoporous magnesium-zinc-silicon xerogels for osteomyelitis treatment and bone repair[J].Int J Nanomedicine,2015, 22(10):4071-4080.[35]Kanellakopoulou K, Giamarellos-Bourboulis EJ. Carrier system for the local delivery of antibiotics in bone infections[J].Drugs,2000, 59:1223-1232.[36]He N, Hu J, Liu H, et al. Enhancement of vancomycin activity against biofilms by using ultrasound-targeted microbubble destruction[J]. Antimicrob Agents Chemother, 2011, 55:5331-5337.[37]刘立婷，余加林，郜向娜，等.低频超声联合环丙沙星对铜绿假单胞菌生物被膜的杀菌作用及其结构的影响[J].中国超声医学杂志,2011,27(7):577-580.[38]叶银存，余加林，刘立婷，等.低频超声联合盐酸氨溴索对表皮葡萄球菌生物被膜的影响[J].中国超声医学杂志,2012,28(7):581-584. |
