Abstract: Periodontitis is closely related to diabetes. Diabetes is one of the systemic stimulants of periodontitis, and Periodontitis can aggravate the severity of diabetes and the status of metabolic disorders. Periodontal non-surgical treatment(PNT) is of great significance in this bi-directional relationship. It can significantly improve the state of periodontal support tissue , reduce the expression of inflammatory factors in serum and gingival crevicular fluid，which was found that these in connection with a notable reduction of type II fimA of porphyromonas gingivalis and the suppression of related inflammatory genes, such as immuno-inflammatory gene in endothelial progenitor cells. Studies have shown that PNT can alleviate insulin resistance by reducing the release of insulin-antagonizing adipokines and increasing the production of insulin-sensitizing adipokines, and may also benefit glucose and lipid metabolism by improving the expression of metabolism and inflammation-related genes in fat tissue. Identifying the effect and related mechanisms of PNT on type 2 diabetes mellitus with chronic periodontitis patients could provide new theoretical evidence for the prevention and therapy of type 2 diabetes mellitus and complications.

Key words: Periodontal non-surgical treatment, Type 2 diabetes mellitus, Periodontitis