Abstract: Abstract Objective We are going to investigate the relationship between preterm premature rupture of membranes (pPROM) and periodontal diseases by comparing the periodontal conditions and serum levels of Il-6, CRP and PCT in pregnant women with pPROM and those are none preterm rupture of membranes (nPROM). Methods In this study, 40 cases of pPROM and 40 cases of nPROM from the maternity ward of Shengjing hospital affiliated to China medical university were selected. After signing the informed consent, clinical periodontal examination was performed to determine whether the pregnant women had periodontitis to be further divided into four groups. Results The prevalence of periodontitis in pPROM pregnant women was higher than that in nPROM pregnant women (?2=5.115, P=0.024). PD (P=0.001) and SBI (P=0.037) in group A were significantly higher than those in group C. PD of group B was significantly higher than that of group D (P=0.011).There was no statistically significant difference in PLI between groups A and C, B and D, C and D, with P values of 0.292, 0.532 and 0.060, respectively. The levels of IL-6 (P=0.002), CRP (P=0.016) and PCT (P=0.009) in group A were significantly higher than that in group B, and the levels of IL-6 (P=0.009) and CRP (P=0.002) in group C were significantly higher than that in group D. There was no statistically significant difference in PCT levels among other groups except for group A and B (P >0.05). Conclusion pPROM may indicate a higher prevalence of periodontitis. The host's immune response may be one of the key pathways through which PD and pPROM interact, and IL-6 and CRP may be crucial in this process.

Key words: Periodontal disease, Premature rupture of membranes, Periodontitis, Serum