口腔扁平苔藓黏膜病损区微生物群落分析

Abstract

Abstract: Objective　 The purpose of this study was to investigate the diversity, composition and structure of related microorganisms in patients with oral lichen planus (OLP). Methods　 The 16S rDNA gene sequencing of buccal or tongue mucosa samples from 12 reticular OLP patients, 12 erosive OLP patients and 8 healthy volunteers was carried out using sterile swabs to preliminarily explore the microbial dysbiosis of OLP patients. Results　 The relative abundance of bacteria of the OLP was significantly higher than that of the control group, including Eikenella, Alysiella, morococcus pneumoniae, Prevotella marshii, Leptotrichia buccalis c-1013-b and Granulicatella elegans. Among them, the relative abundance of Prevotella marshii was significantly higher in erosive OLP than in reticular OLP(P=0.0009). The relative abundance of Sediminibacterium and Streptococcus salivarius subsp. salivarius increased in the control group. Conclusions　The results showed that the characteristics of related microorganisms in the OLP were different from those in the control group. In order to determine the effective prevention and treatment strategies of OLP, further study on the diversity of OLP related microbial communities is of great importance.

Key words: oral lichen planus, microbiome, 16S rDNA gene, swab samples

CLC Number:

R781.59

References 28

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Analysis of microbial communities in mucosal lesions of oral lichen planus

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