硅酸钙生物材料诱导牙源性干细胞成牙/成骨分化机制的研究进展

Abstract

Abstract: Calcium silicate cements (CSCs) are biomaterials with tri- and di-calcium silicates as their dominant ingredients, which exhibit excellent biocompatibility, antibacterial, anti-inflammatory properties and promote stem cells odonto/osteogenic differentiation. CSCs are widely used in bone tissue engineering, dentistry, plastic surgery and other fields. In recent years, MTA, a represent product of CSCs, has been widely applied in pulp capping, pulpotomy, perforation repairment, apical barriers and other endodontic treatments. Furthermore, the application of nanotechnology has significantly improved the physical and chemical properties, the ion release characteristics and bioactivity of CSCs. The interaction between signaling molecules (such as growth and differentiation factors) activation/expression, responsive dental stem cells and the microenvironment are considered as the possible mechanism underlying the promotion of odonto/osteogenic regeneration induced by CSCs. This article will review the related mechanism of CSCs on odonto/osteogenic differentiation of dental stem cells.

Key words: calcium silicate cements, dental stem cells, odonto/osteogenesis, molecular signaling

CLC Number:

R783.1

References 40

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Research progress of the mechanism of odonto/osteogenic differentiation of dental stem cells induced by calcium silicate cements

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