双膦酸盐在正畸治疗中的新进展与展望

Abstract

Abstract: Bisphosphonates （BPs）effectively inhibit bone resorption, not only affect bone metabolism, but also have a certain effect on tooth movement in orthodontic treatment. Recent new studies have shown that BPs interfere with bone resorption of osteoclasts through different mechanisms, restrict the movement of anchorage teeth, reduce root resorption, and maintain the effect of rapid palatal expansion. Therefore, BPs can accelerate the press of bone reconstruction in craniofacial stretching, and prevent the infection induced by bone nail and the tooth loosening. This article summarizes new progress and prospect of BPs regarding to the mechanism and applicationt in orthodontic treatment.

Key words: Bisphosphonates Orthodontic Root resorption Rapid palatal expansion Mandibular osteogenic distraction

CLC Number:

R783.5

References 16

[1]	Halasy-Nagy J M, Rodan G A, Reszka A A.Inhibition of bone resorption by alendronate and risedronate does not require osteoclast apoptosis[J].Bone, 2001, 29(6):553-559
[2]	Licata A A.Discovery,Clinical Development,and Therapeutic Uses of Bisphosphonates[J].Annals of Pharmacotherapy, 2005, 39(4):668-677
[3]	Russell R G G, Rogers Michael J, Frith Julie C, et al.The pharmacology of bisphosphonates and new insights into their mechanisms of action[J].Journal of Bone and Mineral Research, 2011, 14(S2):53-65
[4]	Ruggiero S L, Dodson T B, Assael L A, et al.American Association of Oral and Maxillofacial Surgeons Position Paper on Bisphosphonate-Related Osteonecrosis of the Jaws-2009 Update[J].Journal of Oral and Maxillofacial Surgery, 2009, 67(5):2-12
[5]	Sato Y S, H; Kobayashi, Y; .Bisphosphonate administration alters subcellular localization of vacuolar-type H+-ATPase and cathepsin K in osteoclasts during experimental movement of rat molars[J].ANATOMICAL RECORD , 2000, 260(1 ):72-80
[6]	Franzoni J S, Soares F M P, Zaniboni E, et al.Zoledronic acid and alendronate sodium and the implications in orthodontic movement[J].Orthodontics & Craniofacial Research, 2017, 20(3):164-169
[7]	Grimm S, Walter C, Pabst A, et al.Effect of compressive loading and incubation with clodronate on the RANKLOPG system of human osteoblasts[J].Journal of Orofacial Orthopedics Fortschritte der Kieferorthop?die, 2015, 76(6):531-542
[8]	Liu L, Igarashi K, Haruyama N, et al.Effects of local administration of clodronate on orthodontic tooth movement and root resorption in rats[J].European Journal of Orthodontics, 2004, 26(5):469-473
[9]	Keles A, Grunes B, Difuria C, et al.Inhibition of tooth movement by osteoprotegerin vspamidronate under conditions of constant orthodontic force[J].European Journal of Oral Sciences, 2007, 115(2):131-136
[10]	Sirisoontorn I, Hotokezaka H, Hashimoto M, et al.Orthodontic tooth movement and root resorption in ovariectomized rats treated by systemic administration of zoledronic acid[J].American Journal of Orthodontics and Dentofacial Orthopedics, 2012, 141(5):563-573
[11]	Naka? E, Lauc T, Tiro A, et al.Dose- and time-dependent effects of clodronate on orthodontic tooth movement[J].Bosnian Journal of Basic Medical Sciences, 2017, 17(1):23-28
[12]	Seifi M, Asefi S, Hatamifard G, et al.Effect of local injection of Zolena,zoledronic acid made in Iran,on orthodontic tooth movement and root and bone resorption in rats[J].Journal of Dental Research, Dental Clinics, Dental Prospects, 2017, 11(4):257-264
[13]	Exposto C R, Oz U, Callard J S, et al.Oncologic doses of zoledronic acid induce site specific suppression of bone modelling in rice rats[J].Orthod Craniofac Res, 2017, 20(1):83-88
[14]	Koehne T, Kahl-Nieke B, Amling M, et al.Inhibition of bone resorption by bisphosphonates interferes with orthodontically induced midpalatal suture expansion in mice[J].Clinical Oral Investigations, 2018, 22(6):2345-2351
[15]	Pampu A A, Dolanmaz D, Tüz H H, et al.Experimental Evaluation of the Effects of Zoledronic Acid on Regenerate Bone Formation and Osteoporosis in Mandibular Distraction Osteogenesis[J].Journal of Oral and Maxillofacial Surgery, 2006, 64(8):1232-1236
[16]	Pampu A A, Dolanmaz D, Tüz H H, et al.Histomorphometric Evaluation of the Effects of Zoledronic Acid on Mandibular Distraction Osteogenesis in Rabbits[J].Journal of Oral and Maxillofacial Surgery, 2008, 66(5):905-910

New progress and Prospect of bisphosphonate in orthodontic treatment

Knowledge

Abstract

Cite this article

share this article

References 16

Related Articles 15

Recommended Articles

Metrics

Comments

[1]	. Analysis on buccal bone thickness of mandibular anterior teeth in malocclusion adolescents in different growing periods [J]. , 2020, 40(7): 618-623.
[2]	. The upper airway change of patients treated with Mandibular Molars Distalization by Clear Aligner [J]. , 2020, 40(6): 531-534.
[3]	qihao lu. Correlation between vertical facial type and tooth-alveolar bone complex morphology in maxillary posterior teeth of adult patients with skeletal II [J]. , 2020, 40(5): 432-436.
[4]	Ying-Qian WU. Malocclusion assessment index and its application in early orthodontic treatment [J]. , 2020, 40(5): 476-480.
[5]	. Study of morphological feature and mechanism of maxillofacial bone abnormalities secondary to chronic kidney disease in mice [J]. , 2020, 40(5): 404-410.
[6]	. Study of the vertically impacted maxillary incisors’ root development during orthodontic traction [J]. , 2020, 40(4): 330-333.
[7]	SHAO xinyi. The study of orthodontic orthognathic treatment of skeletal class Ⅲ patients by using visual analogue score (VAS) [J]. , 2020, 40(4): 334-337.
[8]	. Comparison of two kinds of micro-implant anchorage methods in the orthodontic treatment with teeth extraction [J]. , 2020, 40(4): 338-341.
[9]	. Study on the experimental conditions of nano-indentation test for investigating the viscoelastic properties of human periodontal ligament [J]. , 2020, 40(4): 313-318.
[10]	. Effects of different types of malocclusions on morphology and function of temporomandibular joint [J]. , 2020, 40(4): 381-384.
[11]	. The Expression of Hedgehog downstream signals in orthodontic bone remodeling. [J]. , 2020, 40(4): 293-298.
[12]	. [J]. , 2020, 40(3): 219-222.
[13]	. Clinical study of two methods for the treatment of Class Ⅱ division 2 of different ages [J]. , 2020, 40(3): 209-214.
[14]	. Research of changes of 61 patients’periodontal condition following orthodontic extrusion in retaining residual root treatment [J]. , 2020, 40(3): 215-218.
[15]	. Analysis of the soft and hard tissue changes after orthognathic surgery in patients with facial asymmetry by threedimensional photography combined with conebeam computed tomography scans [J]. , 2020, 40(2): 117-120.