间充质干细胞来源的脱细胞基质及其研究进展

Abstract

Abstract: Stem cells have been a hotspot of medical research at home and abroad, especially in the field of regenerative medicine. As one of the most widely used stem cells, mesenchymal stem cell derived extracellular matrix（MSC-ECM） has been successfully isolated and proved to be effective in cell proliferation, development and orientated differentiation and so on through recent research. Furthermore, because of its rich resources, preventing pathogen transmission and reducing autoimmunity, MSC-ECM is considered to be an ideal biological material for tissue engineering. This comprehensive review mainly focused on concept, ingredient, the acquisition methods, research progress and application prospect of mesenchymal stem cell-derived extracellular matrix.

Key words: Mesenchymal stem cell, Extracellular matrix, Tissue engineering, Bone regeneration

CLC Number:

R329.28

References 48

[1]	Squillaro T, Peluso G, Galderisi U.Clinical trials with mesenchymal stem cells: an update[J].Cell Transplant, 2016, 25(5):829-848
[2]	Madrigal M, Rao KS.Riordan NHA review of therapeutic effects of mesenchymal stem cell secretions and induction of secretory modification by different culture methods[J].J Transl Med, 2014, 12(1):260-
[3]	Kupcova Skalnikova H.Proteomic techniques for characterisation of mesenchymal stem cell secretome[J].Biochimie, 2013, 95(12):2196-2211
[4]	Hynes RO, Naba A.Overview of the matrisome--an inventory of extracellular matrix constituents and functions[J].CSH Perspect Biol, 2012, 4(1):a004903-
[5]	Sainio A, J?rvel?inen, H.Extracellular matrix macromolecules: potential tools and targets in cancer gene therapy[J].Mol Cell Ther, 2014, 2(1):14-
[6]	Rana D, Zreiqat H, Benkirane-Jessel N, et al.Development of decellularized scaffolds for stem cell-driven tissue engineering[J].J Tissue Eng Regen Med, 2017, 11(4):942-965
[7]	Hoshiba T, Kawazoe N, Chen G.Preparation of cell-derived decellularized matrices mimicking native ECM during the osteogenesis and adipogenesis of mesenchymal stem cells[J]. Methods Mol Biol, 2017, 1577: 71-86.
[8]	Wei F, Qu C, Song T, et al.Vitamin C treatment promotes mesenchymal stem cell sheet formation and tissue regeneration by elevating telomerase activity[J].J Cell Physiol, 2012, 227(9):3216-3224
[9]	Guo P, Zeng J J, Zhou N.A novel experimental study on the fabrication and biological characteristics of canine bone marrow mesenchymal stem cells sheet using vitamin C[J].Scanning, 2015, 37(1):42-8
[10]	Zeiger A S, Loe F C, Li R, et al.Macromolecular crowding directs extracellular matrix organization and mesenchymal stem cell behavior[J].PLoS One, 2012, 7(5):e37904-
[11]	Sorushanova A, Delgado L M, Wu Z, et al.The collagen suprafamily: from biosynthesis to advanced biomaterial development[J].Adv Mater, 2019, 31(1):e1801651-
[12]	Xing Q, Yates K, Tahtinen M, et al.Decellularization of fibroblast cell sheets for natural extracellular matrix scaffold preparation[J].Tissue Eng Part C Methods, 2015, 21(1):77-87
[13]	Lu H, Hoshiba T, Kawazoe N, et al.Comparison of decellularization techniques for preparation of extracellular matrix scaffolds derived from three-dimensional cell culture[J].J Biomed Mater Res A, 2012, 100(9):2507-16
[14]	Ingrassia D, Sladkova M, Palmer M, et al.Stem cell-mediated functionalization of titanium implants[J].J Mater Sci Mater Med, 2017, 28(9):133-
[15]	Harvey A, Yen T Y, Aizman I, et al.Proteomic analysis of the extracellular matrix produced by mesenchymal stromal cells: implications for cell therapy mechanism[J].PLoS One, 2013, 8(11):e79283-
[16]	Wang X, Chen Z, Zhou B, et al.Cell-sheet-derived ECM coatings and their effects on BMSCs responses[J].ACS Appl Mater Interfaces, 2018, 10(14):11508-11518
[17]	Deutsch E R, Guldberg R E.Stem cell-synthesized extracellular matrix for bone repair[J].J Mater Chem, 2010, 20(40):B-i
[18]	Ragelle H, Naba A, Larson B L, et al.Comprehensive proteomic characterization of stem cell-derived extracellular matrices[J]. Biomater, 2017, 128: 147-159.
[19]	Liu X, Zhou L, Chen X, et al.Culturing on decellularized extracellular matrix enhances antioxidant properties of human umbilical cord-derived mesenchymal stem cells[J]. Mater Sci Eng C Mater Biol Appl, 2016, 61: 437-448.
[20]	Baroncelli M, Van BDE, Chatterji S, et al.Human osteoblast-derived extracellular matrix with high homology to bone proteome is osteopromotive[J]. Tissue Eng Part A, 2018, ten.TEA: 2017.0448.
[21]	Chen XD, Dusevich V, Feng JQ, et al.Extracellular matrix made by bone marrow cells facilitates expansion of marrow-derived mesenchymal progenitor cells and prevents their differentiation into osteoblasts[J].J Bone Miner Res, 2007, 22(12):1943-56
[22]	Anasiz Y, Ozgul RK, Uckan-Cetinkaya D.A new chapter for mesenchymal stem cells: decellularized extracellular matrices[J].Stem Cell Rev, 2017, 13(5):587-597
[23]	Lai Y, Sun Y, Skinner CM, et al.Reconstitution of marrow-derived extracellular matrix ex vivo: a robust culture system for expanding large-scale highly functional human mesenchymal stem cells[J].Stem Cells Dev, 2010, 19(7):1095-107
[24]	Antebi B, Zhang Z, Wang Y, et al.Stromal-cell-derived extracellular matrix promotes the proliferation and retains the osteogenic differentiation capacity of mesenchymal stem cells on three-dimensional scaffolds[J].Tissue Eng Part C Methods, 2015, 21(2):171-181
[25]	Lu H, Hoshiba T, Kawazoe N, et al.Autologous extracellular matrix scaffolds for tissue engineering[J].Biomater, 2011, 32(10):2489-2499
[26]	Onishi T, Shimizu T, Akahane M, et al.Osteogenic extracellular matrix sheet for bone tissue regeneration[J]. Eur Cell Mater, 2018, 36: 68-80.
[27]	Hoch A I, Mittal V, Mitra D, et al.Cell-secreted matrices perpetuate the bone-forming phenotype of differentiated mesenchymal stem cells[J]. Biomed Res Int, 2016, 74: 178.
[28]	Sun Y, Li W, Lu Z, et al.Rescuing replication and osteogenesis of aged mesenchymal stem cells by exposure to a young extracellular matrix[J].FASEB J, 2011, 25(5):1474-1485
[29]	Baroncelli M, Van Der Eerden B C, Kan Y Y, et al.Comparative proteomic profiling of human osteoblast-derived extracellular matrices identifies proteins involved in mesenchymal stromal cell osteogenic differentiation and mineralization[J].J Cell Physiol, 2018, 233(1):387-395
[30]	Rao Pattabhi S, Martinez J S, Keller T C.Decellularized ECM effects on human mesenchymal stem cell stemness and differentiation[J].Differ, 2014, 88(4-5):131-43
[31]	Schnabel M, Marlovits S, Eckhoff G, et al.Dedifferentiation-associated changes in morphology and gene expression in primary human articular chondrocytes in cell culture[J].Osteoarthr Cartil, 2002, 10(1):62-70
[32]	Yang Y, Lin H, Shen H, et al.Mesenchymal stem cell-derived extracellular matrix enhances chondrogenic phenotype of and cartilage formation by encapsulated chondrocytes in vitro and in vivo[J]. Acta Biomater, 2018, 69: 71-82.
[33]	Dzobo K, Turnley T, Wishart A, et al.Fibroblast-derived extracellular matrix induces chondrogenic differentiation in human adipose-derived mesenchymal stromalstem cells in vitro[J].Int J Mol Sci, 2016, 17(8):1259-
[34]	Mao Y, Block T, Singh-Varma A, et al.Extracellular matrix derived from chondrocytes promotes rapid expansion of human primary chondrocytes in vitro with reduced dedifferentiation[J]. Acta Biomater, 2019, 85: 75-83.
[35]	Mao Y, Hoffman T, Wu A, et al.Cell type-specific extracellular matrix guided the differentiation of human mesenchymal stem cells in 3D polymeric scaffolds[J].J Mater Sci Mater Med, 2017, 28(7):100-
[36]	Kwon S H, Lee T J, Park J, et al.Modulation of BMP-2-induced chondrogenic versus osteogenic differentiation of human mesenchymal stem cells by cell-specific extracellular matrices[J].Tissue Eng Part A, 2013, 19(1-2):49-58
[37]	Teixeira F G, Panchalingam K M, Assuncao-Silva R, et al.Modulation of the mesenchymal stem cell secretome using computer-controlled bioreactors: impact on neuronal cell proliferation, survival and differentiation[J]. Sci Rep, 2016, 6: 27791.
[38]	Lee Y B, Lee J Y, Byun H, et al.One-step delivery of a functional multi-layered cell sheet using a thermally expandable hydrogel with controlled presentation of cell adhesive proteins[J].Biofabrication, 2018, 10(2):025001-
[39]	Xu Y, Shi T, Xu A, et al.D spheroid culture enhances survival and therapeutic capacities of MSCs injected into ischemic kidney[J].J Cell Mol Med, 2016, 20(7):1203-13
[40]	Pati F, Song T H, Rijal G, et al.Ornamenting 3D printed scaffolds with cell-laid extracellular matrix for bone tissue regeneration[J]. Biomater, 2015, 37: 230-241.
[41]	Haraguchi Y, Shimizu T, Sasagawa T, et al.Fabrication of functional three-dimensional tissues by stacking cell sheets in vitro[J].Nat Protoc, 2012, 7(5):850-858
[42]	Kolaparthy L K, Sanivarapu S, Moogla S, et al.Adipose tissue - adequate,accessible regenerative material[J].Int J Stem Cells, 2015, 8(2):121-7
[43]	Topoluk N, Hawkins R, Tokish J, et al.Amniotic mesenchymal stromal cells exhibit preferential osteogenic and chondrogenic differentiation and enhanced matrix production compared with adipose mesenchymal stromal cells[J].Am J Sports Med, 2017, 45(11):2637-2646
[44]	Amable P R, Teixeira M V T, Carias R B V, et al.Protein synthesis and secretion in human mesenchymal cells derived from bone marrow,adipose tissue and Wharton’s jelly[J].Stem Cell Res Ther, 2014, 5(2):53-
[45]	Choi D H, Suhaeri M, Hwang M P, et al.Multi-lineage differentiation of human mesenchymal stromal cells on the biophysical microenvironment of cell-derived matrix[J].Cell Tissue Res, 2014, 357(3):781-92
[46]	Caplan A I, Correa D.The MSC: an injury drugstore[J].Cell Stem Cell, 2011, 9(1):11-5
[47]	Takewaki M, Kajiya M, Takeda K, et al.MSCECM cellular complexes induce periodontal tissue regeneration[J].J Den Res, 2017, 96(9):984-991
[48]	Lee D J, Lee J M, Kim E J, et al.Bio-implant as a novel restoration for tooth loss[J].Sci Rep, 2017, 7(1):7414-

Mesenchymal stem cell derived extracellular matrix and its research progress

Knowledge

Abstract

Cite this article

share this article

References 48

Related Articles 15

Recommended Articles

Metrics

Comments

[1]	. Research progress on scaffolds in the dental pulp revascularization [J]. , 2020, 40(4): 371-375.
[2]	. Effects of microspheres modified with collagen I on the adhesion, proliferation and osteogenesis of BMSCs [J]. , 2020, 40(4): 299-303.
[3]	. Osteogenic effects of small molecules on bone defect repair [J]. , 2019, 39(8): 739-743.
[4]	. Effect of autogenous bone graft on distal bone defect of the second molar after the extraction of the impacted third molar [J]. , 2019, 39(7): 624-627.
[5]	. Application of platelet concentrate in oral implantation [J]. , 2019, 39(7): 636-641.
[6]	. Performance study of two new collagen membranes for guiding bone tissue regeneration in vivo and in vitro [J]. , 2019, 39(6): 481-487.
[7]	. The association between Matrix metalloproteinase 13 and common oral disease [J]. , 2019, 39(5): 468-471.
[8]	Yang LIU. The chitosan drug delivery system and its application in bone tissue engineering [J]. , 2019, 39(4): 354-359.
[9]	. Research progress of bone regeneration on jaw defect guided by GBR technique [J]. , 2019, 39(3): 261-265.
[10]	. Application of poly(lactic-co-glycolic acid) in bone tissue engineering scaffold materials [J]. , 2019, 39(2): 167-170.
[11]	. Advantages of long-term stability of guided bone regeneration augmentation for alveolar bone reconstruction compared with autogenous bone graft [J]. , 2019, 39(1): 60-62.
[12]	. Progress of mesenchymal stem cell related growth factor in alveolar bone repair [J]. , 2019, 39(1): 66-70.
[13]	Bin binGE. The effect of oxytocin on tissue metabolism, repair and regeneration [J]. , 2018, 38(9): 856-859.
[14]	. Effects of Gel - like Scaffold on Proliferation of Human Dental Pulp Stem Cells. [J]. , 2018, 38(7): 587-591.
[15]	. An experimental study of the application of adipose-derived stem cells compositing osteoblastic mesenchymal stem cell sheets to improveing bone formation in calvarial defects in rabbits [J]. , 2018, 38(7): 0-0.