LncRNA调控PDLSCs成骨分化的研究进展

Abstract

Abstract: Periodontal ligament stem cells（PDLSCs） are a type of mesenchymal stem cells (MSCs),which are seed cells of periodontal reconstruction and repair．In normal, the osteogenic differentiation capacity of PDLSCs is stable, maintaining the dynamic balance of osteogenesis and osteoclasia. However, the differentiation capacity of PDLSCs can be destroyed in the inflammatory environment, leading to loss of periodontal tissue, which can’t recover spontaneously. Promoting the regeneration capacity of PDLSCs is an important way of periodontal regeneration. Long non-coding RNA(LncRNA) can participate in the inflammatory response in several aspects and be related to the osteogenic differentiation of PDLSCs，and increasingly become a hot spot of research. This article reviewed the mechanism of LncRNA regulating the osteogenic differentiation of PDLSCs.

Key words: LncRNA, PDLSCs, Osteogenic differentiation, Periodontal regeneration

CLC Number:

R781.42

References 40

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Research Progress of LncRNA Regulating Osteogenic Differentiation of PDLSCs

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