›› 2020, Vol. 40 ›› Issue (5): 465-470.

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Research progress of expression and action mechanism of 14-3-3 protein in oral squamous cell carcinoma

  

  • Received:2019-12-16 Revised:2020-02-19 Online:2020-05-26 Published:2020-06-08

Abstract: The 14-3-3 protein family is ubiquitous in eukaryotic cells and is a highly conserved family of acidic proteins. It acts as an adaptor protein involved in various regulatory processes of cells such as cell cycle, metabolism, apoptosis, and incidence of diseases. In recent years, studies have found that 14-3-3 protein is associated with the occurrence and development of various tumors, and can be used as a new target for early diagnosis and treatment of diseases. This article briefly describes the expression and role of the 14-3-3 protein family in oral squamous cell carcinoma.

Key words: 14-3-3 protein, oral squamous cell carcinoma, lymph node metastasis, targeted therapy

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